使用潜在标记霍克斯过程的分层流行病模型。

IF 1.9 4区 数学 Q2 BIOLOGY Mathematical Biosciences Pub Date : 2024-07-18 DOI:10.1016/j.mbs.2024.109260
Stamatina Lamprinakou , Axel Gandy
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引用次数: 0

摘要

我们将 Lamprinakou 等人(2023 年)提出的非结构化均匀混合流行病模型扩展到按年龄段分层的有限人口。我们使用一个潜在的标记霍克斯过程来模拟实际未观察到的感染情况,并将报告的总感染情况作为由基本霍克斯过程驱动的随机量。我们采用核密度粒子滤波器(KDPF)来推断标记计数过程、每个年龄组的瞬时繁殖数量,并预测疫情在不久将来的发展轨迹。与同质非结构流行病模型的推理算法相比,考虑个体年龄的不均匀性并不会显著增加推理算法的计算成本。我们证明,考虑到个体在年龄上的异质性,我们可以得出每个年龄组的瞬时繁殖数量,从而对相关群体的干预和行为变化进行实时测量。我们在英国各地方当局的合成数据集和 COVID-19 报告病例上说明了所提推断算法的性能,并将我们的模型与非结构化同质混合流行病模型进行了比较。我们的论文 "展示 "了一种可用于年龄以外因素分层的方法。
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Stratified epidemic model using a latent marked Hawkes process

We extend the unstructured homogeneously mixing epidemic model introduced by Lamprinakou et al. (2023) to a finite population stratified by age bands. We model the actual unobserved infections using a latent marked Hawkes process and the reported aggregated infections as random quantities driven by the underlying Hawkes process. We apply a Kernel Density Particle Filter (KDPF) to infer the marked counting process, the instantaneous reproduction number for each age group and forecast the epidemic’s trajectory in the near future. Taking into account the individual inhomogeneity in age does not increase significantly the computational cost of the proposed inference algorithm compared to the cost of the proposed algorithm for the homogeneously unstructured epidemic model. We demonstrate that considering the individual heterogeneity in age, we can derive the instantaneous reproduction numbers per age group that provide a real-time measurement of interventions and behavioural changes of the associated groups. We illustrate the performance of the proposed inference algorithm on synthetic data sets and COVID-19-reported cases in various local authorities in the UK, and benchmark our model to the unstructured homogeneously mixing epidemic model. Our paper is a “demonstration” of a methodology that might be applied to factors other than age for stratification.

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来源期刊
Mathematical Biosciences
Mathematical Biosciences 生物-生物学
CiteScore
7.50
自引率
2.30%
发文量
67
审稿时长
18 days
期刊介绍: Mathematical Biosciences publishes work providing new concepts or new understanding of biological systems using mathematical models, or methodological articles likely to find application to multiple biological systems. Papers are expected to present a major research finding of broad significance for the biological sciences, or mathematical biology. Mathematical Biosciences welcomes original research articles, letters, reviews and perspectives.
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