模仿转移灶的术后纺锤细胞结节在接受个性化抗原肽肿瘤疫苗治疗后，68Ga-FAPI-04 摄取量持续升高。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical Nuclear Medicine Pub Date : 2024-11-01 Epub Date: 2024-07-20 DOI:10.1097/RLU.0000000000005371

Yirong Wang, Zhiyong Quan, Yongzhan Nie, Fei Kang, Jing Wang

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引用次数: 0

摘要

摘要：一名 59 岁的女性因胃癌接受了根治性手术和化疗。注射个性化抗原肽肿瘤疫苗后，在 68Ga-FAPI-04 PET/MRI 随访期间发现上腹部有新的结节性病变。为确定可能的假性进展，39 天后，参照实体瘤免疫 PET 反应标准，再次进行了 68Ga-FAPI-04 PET/MRI 检查。该病灶显示 68Ga-FAPI-04 摄取增加，而疫苗注射部位的摄取减少，最终被诊断为术后纺锤形细胞结节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Postoperative Spindle Cell Nodule Mimicking Metastatic Lesion With Persistently Increasing 68 Ga-FAPI-04 Uptake After Receiving Personalized Antigen Peptide Tumor Vaccine.

Abstract: A 59-year-old woman underwent radical surgery and chemotherapy for gastric adenocarcinoma. After the personalized antigen peptide tumor vaccine, a new nodular lesion, in the upper abdomen, was discovered during 68 Ga-FAPI-04 PET/MRI follow-up. To determine possible pseudoprogression, 68 Ga-FAPI-04 PET/MRI was repeated 39 days later, referring to immune PET response criteria in solid tumors. The lesion showed increased 68 Ga-FAPI-04 uptake, whereas uptake in vaccine injection sites decreased, and was ultimately diagnosed as a postoperative spindle cell nodule.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.