专科门诊中强迫症和精神病风险症状的重叠。

IF 2.1 4区 医学 Q3 PSYCHIATRY Early Intervention in Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-07-23 DOI:10.1111/eip.13596
Michelle L West, James Green, Madison E Barber, Shadi Sharif, Victoria Lisowski, Michelle Friedman-Yakoobian
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引用次数: 0

摘要

目的:精神障碍和强迫症(OCD)通常同时存在。同样,阈值以下的精神病症状(精神病临床高危人群;CHR)和强迫症症状(OCS)经常重叠,可能难以区分。本研究旨在重复调查强迫症在临床高危精神病患者样本中的患病率的研究,验证并调查在临床高危精神病患者样本中自我报告强迫症状测量的因子结构,探索强迫症状与临床高危精神病患者和共存症状之间的关系,并调查现实世界中的临床高危精神病患者治疗是否能改善强迫症状和临床高危精神病患者的症状:本研究分析了 CHR 专科门诊收集的基线和 6 个月随访评估的临床档案数据。数据包括 CHR 症状评估、OCS 和临床医生评定的诊断。探索性因子分析研究了OCS的测量结果:在该 CHR 诊所样本中,13.5% 的患者合并有强迫症。自我报告 OCS 测量有两个因素:(1) 检查和计数行为;(2) 侵入性思维和伤害/内疚图像。检查和计数因子与抑郁和社交焦虑相关。侵扰性想法和伤害/内疚图像因子与不寻常的想法内容和社交焦虑明显相关。从基线到 6 个月的随访期间,无论强迫症的诊断结果如何,患者的强迫症状都有所改善。然而,OCS 并未发生变化:这些研究结果证明了自我报告 OCS 测量在 CHR 诊所样本中的有效性,而且 OCS 体验的类型可能会表现出不同的临床模式。此外,与无强迫症的患者相比,合并有强迫症的患者似乎对 CHR 治疗的反应相似。
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Overlap of obsessive compulsive and psychosis risk symptoms in a specialized clinic.

Aim: Psychotic disorders and obsessive-compulsive disorder (OCD) commonly co-occur. Likewise, subthreshold psychosis symptoms (clinical high risk for psychosis; CHR) and obsessive compulsive symptoms (OCS) often overlap and may be difficult to differentiate. This study aimed to replicate research investigating the prevalence of OCD in a CHR clinic sample, validate and investigate factor structure of a self-report OCS measure in a CHR sample, explore how OCS may relate to CHR and co-occurring symptoms, and investigate whether real-world CHR treatment improves OCS and CHR symptoms.

Method: This study analysed archival clinical data from baseline and 6-month follow-up assessments collected by a specialist outpatient CHR clinic. Data included assessments of CHR symptoms, OCS, and clinician-rated diagnosis. Exploratory factor analysis examined the OCS measure.

Results: Within this CHR clinic sample, 13.5% experienced co-morbid OCD. The self-report OCS measure had two factors: (1) checking and counting behaviours and (2) intrusive thoughts and images of harm/guilt. The checking and counting factor correlated with depression and social anxiety. The intrusive thoughts and images of harm/guilt factor significantly correlated with unusual thought content and social anxiety. Between baseline to 6-month follow-up, clients exhibited CHR symptom improvement regardless of OCD diagnosis. However, OCS did not change.

Conclusions: These findings support validity of a self-report OCS measure in a CHR clinic sample and that types of OCS experiences may exhibit different clinical patterns. Additionally, it appears that individuals with comorbid OCD responded similarly to CHR treatment compared to those without OCD.

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来源期刊
Early Intervention in Psychiatry
Early Intervention in Psychiatry 医学-精神病学
CiteScore
4.80
自引率
5.00%
发文量
112
审稿时长
6-12 weeks
期刊介绍: Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.
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