{"title":"有机锂化学与立体选择性生物催化的结合：将芳香族腈转化为手性醇。","authors":"Nicolás Ríos-Lombardía, Gloria Morís-Menéndez, Iván Lavandera, Vicente Gotor-Fernández, Joaquín García-Álvarez","doi":"10.1002/adsc.202400776","DOIUrl":null,"url":null,"abstract":"<p>The front cover illustrates the cooperative action between organolithium reagents (RLi) and alcohol dehydrogenases (ADHs). This chemoenzymatic strategy facilitates the conversion of a range of aromatic nitriles into chiral alcohols. The critical aspect of this research was identifying optimal conditions that allow both RLi and ADHs to function effectively in the same reaction vessel. Details of the studies can be found in the research article by Joaquín García-Álvarez and co-workers (N. Ríos-Lombardía, G. Morís-Menéndez, I. Lavandera, V. Gotor-Fernández, J. García-Álvarez, <i>Adv. Synth. Catal</i>. <b>2024</b>, <i>366</i>, 3144–3152; DOI: 10.1002/adsc.202400460)\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsc.202400776","citationCount":"0","resultStr":"{\"title\":\"Front Cover Picture: Merging Organolithium Chemistry and Stereoselective Biocatalysis: Transformation of Aromatic Nitriles into Chiral Alcohols (Adv. Synth. Catal. 14/2024)\",\"authors\":\"Nicolás Ríos-Lombardía, Gloria Morís-Menéndez, Iván Lavandera, Vicente Gotor-Fernández, Joaquín García-Álvarez\",\"doi\":\"10.1002/adsc.202400776\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The front cover illustrates the cooperative action between organolithium reagents (RLi) and alcohol dehydrogenases (ADHs). This chemoenzymatic strategy facilitates the conversion of a range of aromatic nitriles into chiral alcohols. The critical aspect of this research was identifying optimal conditions that allow both RLi and ADHs to function effectively in the same reaction vessel. Details of the studies can be found in the research article by Joaquín García-Álvarez and co-workers (N. Ríos-Lombardía, G. Morís-Menéndez, I. Lavandera, V. Gotor-Fernández, J. García-Álvarez, <i>Adv. Synth. Catal</i>. <b>2024</b>, <i>366</i>, 3144–3152; DOI: 10.1002/adsc.202400460)\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure>\\n </p>\",\"PeriodicalId\":118,\"journal\":{\"name\":\"Advanced Synthesis & Catalysis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsc.202400776\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Synthesis & Catalysis\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adsc.202400776\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adsc.202400776","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Front Cover Picture: Merging Organolithium Chemistry and Stereoselective Biocatalysis: Transformation of Aromatic Nitriles into Chiral Alcohols (Adv. Synth. Catal. 14/2024)
The front cover illustrates the cooperative action between organolithium reagents (RLi) and alcohol dehydrogenases (ADHs). This chemoenzymatic strategy facilitates the conversion of a range of aromatic nitriles into chiral alcohols. The critical aspect of this research was identifying optimal conditions that allow both RLi and ADHs to function effectively in the same reaction vessel. Details of the studies can be found in the research article by Joaquín García-Álvarez and co-workers (N. Ríos-Lombardía, G. Morís-Menéndez, I. Lavandera, V. Gotor-Fernández, J. García-Álvarez, Adv. Synth. Catal. 2024, 366, 3144–3152; DOI: 10.1002/adsc.202400460)
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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