帕金森病相关蛋白--Parkin介导有丝分裂,而有丝分裂在重度抑郁障碍的病理生理学中起着至关重要的作用。

IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Neurochemistry international Pub Date : 2024-07-22 DOI:10.1016/j.neuint.2024.105808
Yi Zhang
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引用次数: 0

摘要

抑郁症是一种病因复杂的情绪障碍,也是帕金森病最常见的非运动症状。新的研究表明,线粒体功能障碍与重度抑郁症的病理生理学之间存在潜在联系。本综述综合了当前的知识和研究成果,揭示了帕金森病典型相关蛋白 Parkin 与线粒体质量控制机制(如线粒体吞噬、线粒体生物生成和线粒体动态)之间错综复杂的关系,尤其侧重于它们与抑郁症的相关性。此外,本综述还讨论了针对帕金治疗线粒体吞噬的治疗策略,并呼吁在这一领域开展进一步的研究。这些发现表明,通过调节帕金介导的有丝分裂,有望开发出新型抑郁症治疗方法。
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Parkin, a Parkinson's disease-associated protein, mediates the mitophagy that plays a vital role in the pathophysiology of major depressive disorder

Depression is a complex mood disorder with multifactorial etiology and is also the most frequent non-motor symptom of Parkinson's disease. Emerging research suggests a potential link between mitochondrial dysfunction and the pathophysiology of major depressive disorder. By synthesizing current knowledge and research findings, this review sheds light on the intricate relationship between Parkin, a protein classically associated with Parkinson's disease, and mitochondrial quality control mechanisms (e.g., mitophagy, mitochondrial biogenesis, and mitochondrial dynamic), specifically focusing on their relevance in the context of depression. Additionally, the present review discusses therapeutic strategies targeting Parkin-medicated mitophagy and calls for further research in this field. These findings suggest promise for the development of novel depression treatments through modulating Parkin-mediated mitophagy.

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来源期刊
Neurochemistry international
Neurochemistry international 医学-神经科学
CiteScore
8.40
自引率
2.40%
发文量
128
审稿时长
37 days
期刊介绍: Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.
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