CD8+CD60+T 细胞与感染艾滋病毒儿童的疾病进展。

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Annals of clinical and laboratory science Pub Date : 2024-05-01

Tamar A Smith-Norowitz, Haram Abdelmajid, Yecheskel S Gold, Stephan Kohlhoff

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引用次数: 0

摘要

目的CD60 是一种在血液淋巴细胞上表达的 T 细胞标记。CD8+CD60+ T 细胞可能在人类免疫缺陷病毒-1（HIV-1）引起的炎症反应中发挥作用。我们的实验室证明，与 HIV 阴性受试者相比，HIV 阳性受试者的 CD8+CD60+ T 细胞数量更高。本研究评估了处于 HIV-1 疾病不同阶段的 HIV 阳性儿童血液中 CD8+CD60+ 的数量。CD8+CD60+ T 细胞在 HIV 发病机制中的功能尚不清楚：方法：测量 HIV 阳性儿童（20 人）和 HIV 阴性儿童（10 人）血液中的 CD8+CD60+ T 细胞（流式细胞术）。根据与艾滋病毒感染相关的症状/诊断，将感染艾滋病毒的儿童分为四个临床类别（N、A、B、C）。根据临床类别，比较 HIV 阳性与 HIV 阴性患儿的 CD8+CD60+ T 细胞数量（Wilcoxon 符号秩检验）：结果：HIV 阳性儿童的 CD8+CD60+ T 细胞数量高于 HIV 阴性儿童（P=P=0.0158）：结论：HIV 阳性儿童的 CD8+CD60+ T 细胞较高，可能是疾病进展的标志。

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CD8+CD60+T Cells and Disease Progression in Children Livingwith HIV.

Objective: CD60 is a T cell marker expressed on blood lymphocytes. CD8+CD60+ T cells may play a role in inflammatory responses due to human immunodeficiency virus-1 (HIV-1). Our laboratory demonstrated that CD8+CD60+ T cells are higher in HIV positive compared with HIV negative subjects. The present study evaluated numbers of CD8+CD60+ in blood of HIV positive children at various stages of HIV-1 disease. The function of CD8+CD60+ T cells in HIV pathogenesis is unknown.

Methods: CD8+CD60+ T cells were measured in blood of HIV positive (N=20) and HIV negative (N=10) children (flow cytometry). Children with HIV were classified into four clinical categories (N, A, B, C) based on symptoms/diagnoses related to HIV infection. Numbers of CD8+CD60+ T cells were compared in HIV positive versus HIV negative children (Wilcoxon signed rank test) and based on clinical categories.

Results: CD8+CD60+ T cells were higher in HIV positive compared with HIV negative children (P=<0.0001). CD8+CD60+ T cells in blood of HIV positive children were highest in the C category; these cells were associated with disease progression (P=0.0158).

Conclusion: CD8+CD60+ T cells were higher in HIV positive children and may be a marker for disease progression.

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来源期刊

Annals of clinical and laboratory science 医学-医学实验技术

CiteScore

1.60

自引率

0.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： The Annals of Clinical & Laboratory Science welcomes manuscripts that report research in clinical science, including pathology, clinical chemistry, biotechnology, molecular biology, cytogenetics, microbiology, immunology, hematology, transfusion medicine, organ and tissue transplantation, therapeutics, toxicology, and clinical informatics.