手握强度与冠心病患者死亡率之间的关系：一项 Meta 分析

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-07-25 DOI:10.1002/clc.24322

Meiling Xiao, Yu Lu, Hongqiu Li, Zhonghai Zhao

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引用次数: 0

摘要

背景：在社区人群中，肌肉力量与心血管疾病风险的增加有关。本系统综述和荟萃分析旨在评估弱握力（HGS）与冠状动脉疾病（CAD）患者死亡风险之间的关联：为了进行荟萃分析，我们在 PubMed、Embase、Web of Science、Cochrane Library、Wanfang 和 CNKI 等数据库中进行了广泛搜索，以确定具有纵向随访的观察性研究。考虑到异质性的潜在影响，采用随机效应模型对研究结果进行综合分析：结果：共纳入了 8 项观察性研究，涉及 10 543 名 CAD 患者。在平均 20.4 个月的随访期间，有 1327 名（12.6%）患者死亡。汇总结果显示，基线HGS较弱与随访期间全因死亡风险增加有关（风险比[RR]：1.95，95% 置信区间：1.50 至 2.55，P 2 = 62%）。亚组分析表明，与所有成人 CAD 患者相比，老年 CAD 患者的弱 HGS 与死亡率增加之间的关系更为密切（RR：3.01 vs. 1.60，亚组差异 p = 0.004）。根据研究地点、设计、CAD 亚型、随访时间、分析模型和研究质量评分进行的亚组分析显示了相似的结果（亚组差异 p 均大于 0.05）：结论：基线HGS较弱与CAD患者死亡风险增加有关，尤其是老年CAD患者。

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Association Between Handgrip Strength and Mortality of Patients With Coronary Artery Disease: A Meta-Analysis

Background

Muscular strength has been linked to increased risk of cardiovascular disease in the community population. The aim of this systematic review and meta-analysis is to evaluate the association between weak handgrip strength (HGS) and mortality risk in patients with coronary artery disease (CAD).

Methods

To carry out the meta-analysis, an extensive search was conducted on databases such as PubMed, Embase, Web of Science, Cochrane Library, Wanfang, and CNKI to identify observational studies with longitudinal follow-up. Random-effects models were used to combine the findings, taking into account the potential influence of heterogeneity.

Results

Eight observational studies involving 10 543 patients with CAD were included. During a mean follow-up duration of 20.4 months, 1327 (12.6%) patients died. Pooled results showed that weak HGS at baseline was associated with an increased risk of all-cause mortality during follow-up (risk ratio [RR]: 1.95, 95% confidence interval: 1.50 to 2.55, p < 0.001; I² = 62%). Subgroup analysis suggested a stronger association between weak HGS and increased mortality in older patients with CAD as compared to that of overall adult patients with CAD (RR: 3.01 vs. 1.60, p for subgroup difference = 0.004). Subgroup analyses according to study location, design, subtype of CAD, follow-up duration, analytical model, and study quality scores showed similar results (p for subgroup difference all > 0.05).