Maria Meier, Sina Kantelhardt, Laura Gurri, Christina Stadler, Marc Schmid, Vera Clemens, Aoife O'Donovan, Cyril Boonmann, David Bürgin, Eva Unternaehrer
{"title":"童年创伤与曾有青少年寄宿照料经历的青少年的表观遗传年龄减速有关。","authors":"Maria Meier, Sina Kantelhardt, Laura Gurri, Christina Stadler, Marc Schmid, Vera Clemens, Aoife O'Donovan, Cyril Boonmann, David Bürgin, Eva Unternaehrer","doi":"10.1080/20008066.2024.2379144","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Early adversity increases the risk for mental and physical disorders as well as premature death. Epigenetic processes, and altered epigenetic aging in particular, might mediate these effects. While the literature that examined links between early adversity and epigenetic aging is growing, results have been heterogeneous.<b>Objective:</b> In the current work, we explored the link between early adversity and epigenetic aging in a sample of formerly out-of-home placed young adults.<b>Method:</b> A total of <i>N </i>= 117 young adults (32% women, age <i>mean </i>= 26.3 years, <i>SD </i>= 3.6 years) with previous youth residential care placements completed the Childhood Trauma Questionnaire (CTQ) and the Life Events Checklist (LEC-R) and provided blood samples for the analysis of DNA methylation using the Illumina Infinium MethylationEPIC BeadChip Microarray. Epigenetic age was estimated using Hovarth's and Hannum's epigenetic clocks. Furthermore, Hovarth's and Hannum's epigenetic age residuals were calculated as a proxy of epigenetic aging by regressing epigenetic age on chronological age. The statistical analysis plan was preregistered (https://osf.io/b9ev8).<b>Results:</b> Childhood trauma (CTQ) was negatively associated with Hannum's epigenetic age residuals, <i>β </i>= -.23, <i>p</i> = .004 when controlling for sex, BMI, smoking status and proportional white blood cell type estimates. This association was driven by experiences of physical neglect, <i>β </i>= -.25, <i>p</i> = .001. Lifetime trauma exposure (LEC-R) was not a significant predictor of epigenetic age residuals.<b>Conclusion:</b> Childhood trauma, and physical neglect in particular, was associated with decelerated epigenetic aging in our sample. More studies focusing on formerly institutionalized at-risk populations are needed to better understand which factors affect stress-related adaptations following traumatic experiences.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11275517/pdf/","citationCount":"0","resultStr":"{\"title\":\"Childhood trauma is linked to epigenetic age deceleration in young adults with previous youth residential care placements.\",\"authors\":\"Maria Meier, Sina Kantelhardt, Laura Gurri, Christina Stadler, Marc Schmid, Vera Clemens, Aoife O'Donovan, Cyril Boonmann, David Bürgin, Eva Unternaehrer\",\"doi\":\"10.1080/20008066.2024.2379144\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> Early adversity increases the risk for mental and physical disorders as well as premature death. Epigenetic processes, and altered epigenetic aging in particular, might mediate these effects. While the literature that examined links between early adversity and epigenetic aging is growing, results have been heterogeneous.<b>Objective:</b> In the current work, we explored the link between early adversity and epigenetic aging in a sample of formerly out-of-home placed young adults.<b>Method:</b> A total of <i>N </i>= 117 young adults (32% women, age <i>mean </i>= 26.3 years, <i>SD </i>= 3.6 years) with previous youth residential care placements completed the Childhood Trauma Questionnaire (CTQ) and the Life Events Checklist (LEC-R) and provided blood samples for the analysis of DNA methylation using the Illumina Infinium MethylationEPIC BeadChip Microarray. Epigenetic age was estimated using Hovarth's and Hannum's epigenetic clocks. Furthermore, Hovarth's and Hannum's epigenetic age residuals were calculated as a proxy of epigenetic aging by regressing epigenetic age on chronological age. The statistical analysis plan was preregistered (https://osf.io/b9ev8).<b>Results:</b> Childhood trauma (CTQ) was negatively associated with Hannum's epigenetic age residuals, <i>β </i>= -.23, <i>p</i> = .004 when controlling for sex, BMI, smoking status and proportional white blood cell type estimates. This association was driven by experiences of physical neglect, <i>β </i>= -.25, <i>p</i> = .001. Lifetime trauma exposure (LEC-R) was not a significant predictor of epigenetic age residuals.<b>Conclusion:</b> Childhood trauma, and physical neglect in particular, was associated with decelerated epigenetic aging in our sample. More studies focusing on formerly institutionalized at-risk populations are needed to better understand which factors affect stress-related adaptations following traumatic experiences.</p>\",\"PeriodicalId\":12055,\"journal\":{\"name\":\"European Journal of Psychotraumatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11275517/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Psychotraumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/20008066.2024.2379144\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Psychotraumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/20008066.2024.2379144","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/25 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
摘要
背景:早期逆境会增加精神和身体失调以及过早死亡的风险。表观遗传过程,尤其是表观遗传衰老的改变,可能会介导这些影响。虽然研究早期逆境与表观遗传衰老之间联系的文献越来越多,但结果却不尽相同:在目前的研究中,我们以曾经被安置在家庭外的年轻人为样本,探讨了早期逆境与表观遗传衰老之间的联系:共有 N = 117 名曾被安置在青少年寄宿机构的青壮年(32% 为女性,平均年龄 = 26.3 岁,SD = 3.6 岁)填写了童年创伤问卷(CTQ)和生活事件核对表(LEC-R),并提供了血液样本,以便使用 Illumina Infinium MethylationEPIC BeadChip 芯片分析 DNA 甲基化。表观遗传年龄是使用 Hovarth 和 Hannum 的表观遗传时钟估算的。此外,通过将表观遗传年龄与年代年龄进行回归,计算出 Hovarth 和 Hannum 的表观遗传年龄残差,作为表观遗传衰老的替代指标。统计分析计划已预先登记(https://osf.io/b9ev8):结果:在控制性别、体重指数、吸烟状况和白细胞类型比例估计值的情况下,童年创伤(CTQ)与汉纳姆表观遗传年龄残差呈负相关,β = -.23, p = .004。这种关联由身体被忽视的经历驱动,β = -.25, p = .001。终生创伤暴露(LEC-R)对表观遗传年龄残差的预测作用不显著:结论:在我们的样本中,童年创伤,尤其是身体忽视,与表观遗传衰老减速有关。为了更好地了解哪些因素会影响创伤经历后与压力相关的适应性,需要对曾被机构收容的高危人群进行更多的研究。
Childhood trauma is linked to epigenetic age deceleration in young adults with previous youth residential care placements.
Background: Early adversity increases the risk for mental and physical disorders as well as premature death. Epigenetic processes, and altered epigenetic aging in particular, might mediate these effects. While the literature that examined links between early adversity and epigenetic aging is growing, results have been heterogeneous.Objective: In the current work, we explored the link between early adversity and epigenetic aging in a sample of formerly out-of-home placed young adults.Method: A total of N = 117 young adults (32% women, age mean = 26.3 years, SD = 3.6 years) with previous youth residential care placements completed the Childhood Trauma Questionnaire (CTQ) and the Life Events Checklist (LEC-R) and provided blood samples for the analysis of DNA methylation using the Illumina Infinium MethylationEPIC BeadChip Microarray. Epigenetic age was estimated using Hovarth's and Hannum's epigenetic clocks. Furthermore, Hovarth's and Hannum's epigenetic age residuals were calculated as a proxy of epigenetic aging by regressing epigenetic age on chronological age. The statistical analysis plan was preregistered (https://osf.io/b9ev8).Results: Childhood trauma (CTQ) was negatively associated with Hannum's epigenetic age residuals, β = -.23, p = .004 when controlling for sex, BMI, smoking status and proportional white blood cell type estimates. This association was driven by experiences of physical neglect, β = -.25, p = .001. Lifetime trauma exposure (LEC-R) was not a significant predictor of epigenetic age residuals.Conclusion: Childhood trauma, and physical neglect in particular, was associated with decelerated epigenetic aging in our sample. More studies focusing on formerly institutionalized at-risk populations are needed to better understand which factors affect stress-related adaptations following traumatic experiences.
期刊介绍:
The European Journal of Psychotraumatology (EJPT) is a peer-reviewed open access interdisciplinary journal owned by the European Society of Traumatic Stress Studies (ESTSS). The European Journal of Psychotraumatology (EJPT) aims to engage scholars, clinicians and researchers in the vital issues of how to understand, prevent and treat the consequences of stress and trauma, including but not limited to, posttraumatic stress disorder (PTSD), depressive disorders, substance abuse, burnout, and neurobiological or physical consequences, using the latest research or clinical experience in these areas. The journal shares ESTSS’ mission to advance and disseminate scientific knowledge about traumatic stress. Papers may address individual events, repeated or chronic (complex) trauma, large scale disasters, or violence. Being open access, the European Journal of Psychotraumatology is also evidence of ESTSS’ stand on free accessibility of research publications to a wider community via the web. The European Journal of Psychotraumatology seeks to attract contributions from academics and practitioners from diverse professional backgrounds, including, but not restricted to, those in mental health, social sciences, and health and welfare services. Contributions from outside Europe are welcome. The journal welcomes original basic and clinical research articles that consolidate and expand the theoretical and professional basis of the field of traumatic stress; Review articles including meta-analyses; short communications presenting new ideas or early-stage promising research; study protocols that describe proposed or ongoing research; case reports examining a single individual or event in a real‑life context; clinical practice papers sharing experience from the clinic; letters to the Editor debating articles already published in the Journal; inaugural Lectures; conference abstracts and book reviews. Both quantitative and qualitative research is welcome.