{"title":"Ganospirones A-G,灵芝中七种未被描述的螺旋萜类化合物及其生物活性。","authors":"","doi":"10.1016/j.phytochem.2024.114226","DOIUrl":null,"url":null,"abstract":"<div><p><em>Ganoderma lucidum</em>, a medicinal mushroom with a long history in traditional Chinese medicine, is widely used for chronic diseases. Ganospirones A−G (<strong>1</strong>–<strong>7</strong>), seven pairs of undescribed spiro<em>-</em>meroterpenoids, were isolated from the fruiting bodies of <em>G</em>. <em>lucidum</em>. Their structures including absolute configurations were characterized by using NMR spectroscopic data, ECD computational and X-ray diffraction methods. The anti-inflammatory and anti-renal fibrosis activities of the meroterpenoids <strong>1</strong>–<strong>7</strong> were tested, and the results revealed that (−)<strong>-2</strong> and (+)<strong>-2</strong> could inhibit iNOS expression in lipopolysaccharide-induced RAW264.7 cells at 20 μM.</p></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ganospirones A−G, seven undescribed spiro-meroterpenoids from Ganoderma lucidum and their biological activities\",\"authors\":\"\",\"doi\":\"10.1016/j.phytochem.2024.114226\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>Ganoderma lucidum</em>, a medicinal mushroom with a long history in traditional Chinese medicine, is widely used for chronic diseases. Ganospirones A−G (<strong>1</strong>–<strong>7</strong>), seven pairs of undescribed spiro<em>-</em>meroterpenoids, were isolated from the fruiting bodies of <em>G</em>. <em>lucidum</em>. Their structures including absolute configurations were characterized by using NMR spectroscopic data, ECD computational and X-ray diffraction methods. The anti-inflammatory and anti-renal fibrosis activities of the meroterpenoids <strong>1</strong>–<strong>7</strong> were tested, and the results revealed that (−)<strong>-2</strong> and (+)<strong>-2</strong> could inhibit iNOS expression in lipopolysaccharide-induced RAW264.7 cells at 20 μM.</p></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942224002632\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224002632","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Ganospirones A−G, seven undescribed spiro-meroterpenoids from Ganoderma lucidum and their biological activities
Ganoderma lucidum, a medicinal mushroom with a long history in traditional Chinese medicine, is widely used for chronic diseases. Ganospirones A−G (1–7), seven pairs of undescribed spiro-meroterpenoids, were isolated from the fruiting bodies of G. lucidum. Their structures including absolute configurations were characterized by using NMR spectroscopic data, ECD computational and X-ray diffraction methods. The anti-inflammatory and anti-renal fibrosis activities of the meroterpenoids 1–7 were tested, and the results revealed that (−)-2 and (+)-2 could inhibit iNOS expression in lipopolysaccharide-induced RAW264.7 cells at 20 μM.
期刊介绍:
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.