Ganospirones A-G，灵芝中七种未被描述的螺旋萜类化合物及其生物活性。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Phytochemistry Pub Date : 2024-07-22 DOI:10.1016/j.phytochem.2024.114226

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引用次数: 0

摘要

灵芝是一种历史悠久的传统中药蘑菇，被广泛用于治疗慢性疾病。研究人员从灵芝子实体中分离出了 Ganospirones A-G（1-7），这是 7 对未被描述过的螺旋萜类化合物。利用核磁共振光谱数据、ECD 计算和 X 射线衍射方法对它们的结构（包括绝对构型）进行了表征。结果表明，(-)-2 和 (+)-2 在 20 μM 时能抑制脂多糖诱导的 RAW264.7 细胞中 iNOS 的表达。

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Ganospirones A−G, seven undescribed spiro-meroterpenoids from Ganoderma lucidum and their biological activities

Ganoderma lucidum, a medicinal mushroom with a long history in traditional Chinese medicine, is widely used for chronic diseases. Ganospirones A−G (1–7), seven pairs of undescribed spiro-meroterpenoids, were isolated from the fruiting bodies of G. lucidum. Their structures including absolute configurations were characterized by using NMR spectroscopic data, ECD computational and X-ray diffraction methods. The anti-inflammatory and anti-renal fibrosis activities of the meroterpenoids 1–7 were tested, and the results revealed that (−)-2 and (+)-2 could inhibit iNOS expression in lipopolysaccharide-induced RAW264.7 cells at 20 μM.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.