内镜超声引导下注射氰基丙烯酸酯与经颈静脉肝内门体分流术在预防胃静脉曲张再出血方面的比较

Zhuang Zeng, Zhihong Wang, Jing Jin, Fumin Zhang, Qianqian Zhang, Xuecan Mei, Derun Kong
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引用次数: 0

摘要

研究目的本研究旨在探讨内镜超声(EUS)引导下注射氰基丙烯酸酯(CYA)和经颈静脉肝内门体分流术(TIPSs)治疗肝硬化合并胃静脉曲张破裂患者的有效性和安全性:在这项回顾性研究中,对安徽医科大学第一附属医院于2018年4月至2023年4月期间收治的105例未经非选择性β受体阻滞剂治疗且无门静脉血栓形成的肝硬化合并胃静脉曲张患者进行了评估。将患者分为经颈静脉肝内门体分流术(TIPS)组(n=60)和EUS-CYA组(n=45),以评估术后再出血率、并发症、生存率等因素:随访期间,TIPS 组和 EUS-CYA 组在 3 个月内的再出血率无明显差异(5% vs 2.2%;P= 0.825;10% vs 20%,P= 0.147)。然而,TIPS 组在 6 个月(10% vs 33.3%;P= 0.030)和 1 年或更长时间(11.7% vs 42.2%;P < 0.01)内的再出血率明显低于 EUS-CYA 组。在肝性脑病方面,TIPS 组的发病率明显高于 EUS-CYA 组(20% vs 2.2%;P= 0.006)。此外,两组的存活率没有差异(93.3% vs 97.8%;P= 0.552):TIPS在预防胃底静脉曲张破裂患者再出血方面优于EUS,但肝性脑病的发生率较高,两组患者的长期生存率没有差异。
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Comparison of Endoscopic Ultrasound-guided Cyanoacrylate Injection and Transjugular Intrahepatic Portosystemic Shunt in the Prevention of Gastric Varices Rebleeding.

Objective: The purpose of this study was to investigate the efficacy and safety of endoscopic ultrasound (EUS)-guided injection of cyanoacrylate (CYA) and transjugular intrahepatic portal shunts (TIPSs) in the treatment of patients with cirrhosis with ruptured gastric varices.

Methods: In this retrospective study, 105 patients with liver cirrhosis and gastric varicose veins who were admitted to the First Affiliated Hospital of Anhui Medical University between April 2018 and April 2023 without nonselective β-blockers treatment and no portal vein thrombosis were evaluated. The patients were divided into the transjugular intrahepatic portal shunt (TIPS) group (n = 60) and the EUS-CYA group (n = 45) for the purpose of evaluating postoperative rebleeding rates, complications, survival rates, and other factors.

Results: During the follow-up, there was no significant difference in the rebleeding rates between the TIPS group and EUS-CYA group within 3 months (5% vs 2.2%; P = 0.825; 10% vs 20%, P = 0.147). However, the TIPS group had significantly lower rebleeding rates than the EUS-CYA group at 6 months (10% vs 33.3%; P = 0.030) and 1 year or longer (11.7% vs 42.2%; P < 0.01). In terms of hepatic encephalopathy, the incidence rate of the TIPS group was significantly higher than that of the EUS-CYA group (20% vs 2.2%; P = 0.006). In addition, there was no difference in the survival rates between the two groups (93.3% vs 97.8%; P = 0.552).

Conclusions: TIPS is superior to EUS in preventing rebleeding in patients with ruptured varices of the fundus, but it has a higher incidence of hepatic encephalopathy, and there is no difference in long-term survival between the two groups.

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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
103
审稿时长
3-8 weeks
期刊介绍: Surgical Laparoscopy Endoscopy & Percutaneous Techniques is a primary source for peer-reviewed, original articles on the newest techniques and applications in operative laparoscopy and endoscopy. Its Editorial Board includes many of the surgeons who pioneered the use of these revolutionary techniques. The journal provides complete, timely, accurate, practical coverage of laparoscopic and endoscopic techniques and procedures; current clinical and basic science research; preoperative and postoperative patient management; complications in laparoscopic and endoscopic surgery; and new developments in instrumentation and technology.
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