新陈代谢与造血干细胞的命运:NADPH 的作用。

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-07-24 DOI:10.1016/j.tcb.2024.07.003
Claudia Morganti, Massimo Bonora, Keisuke Ito
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引用次数: 0

摘要

线粒体代谢在造血干细胞生物学调控中发挥着核心作用。线粒体脂肪酸氧化(FAO)是控制造血干细胞自我更新和分化的关键。在此,我们将讨论最近有证据表明线粒体中产生的NADPH可影响造血干细胞的命运。虽然 NADPH 具有多种功能,但造血干细胞显示出高水平的 NADPH,并优先用于胆固醇的生物合成。内源性胆固醇支持细胞外囊泡 (EV) 的生物生成,而细胞外囊泡对维持造血干细胞的特性至关重要。我们还强调了EVs通过自分泌信号在造血过程中的重要作用。阐明线粒体 NADPH 胆固醇轴是健康造血干细胞代谢需求的一部分,将有助于开发治疗血液病的新疗法。
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Metabolism and HSC fate: what NADPH is made for.

Mitochondrial metabolism plays a central role in the regulation of hematopoietic stem cell (HSC) biology. Mitochondrial fatty acid oxidation (FAO) is pivotal in controlling HSC self-renewal and differentiation. Herein, we discuss recent evidence suggesting that NADPH generated in the mitochondria can influence the fate of HSCs. Although NADPH has multiple functions, HSCs show high levels of NADPH that are preferentially used for cholesterol biosynthesis. Endogenous cholesterol supports the biogenesis of extracellular vesicles (EVs), which are essential for maintaining HSC properties. We also highlight the significance of EVs in hematopoiesis through autocrine signaling. Elucidating the mitochondrial NADPH-cholesterol axis as part of the metabolic requirements of healthy HSCs will facilitate the development of new therapies for hematological disorders.

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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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