褪黑激素对双酚 F 和 S 诱导的骨骼损伤的保护作用:大鼠形态计量学和组织学研究。

IF 2 3区 医学 Q2 ANATOMY & MORPHOLOGY Annals of Anatomy-Anatomischer Anzeiger Pub Date : 2024-07-23 DOI:10.1016/j.aanat.2024.152314
Firuze Turker Yavas , Figen Sevil Kilimci , Ayse Nur Akkoc , Hande Sultan Sahiner , Özge Bardakci Yilmaz
{"title":"褪黑激素对双酚 F 和 S 诱导的骨骼损伤的保护作用:大鼠形态计量学和组织学研究。","authors":"Firuze Turker Yavas ,&nbsp;Figen Sevil Kilimci ,&nbsp;Ayse Nur Akkoc ,&nbsp;Hande Sultan Sahiner ,&nbsp;Özge Bardakci Yilmaz","doi":"10.1016/j.aanat.2024.152314","DOIUrl":null,"url":null,"abstract":"<div><p>This study aimed to evaluate the potential effects of Bisphenol F and S exposure on the skeletal structures of Sprague-Dawley rats. Given the increasing concern about the potential endocrine-disrupting effects of Bisphenol analogs on bone health, this research sought to elucidate their impact in conjunction with Melatonin. Using 80 male Sprague Dawley rats, bones were subjected to a 3-point bending test to assess mechanical properties, and histopathological evaluation was conducted after fixation and decalcification. Statistical analysis was performed using SPSS. The results of the mechanical tests revealed significant differences in deformation and elastic modulus values between groups treated with Bisphenol F+Melatonin and Bisphenol S+Melatonin compared to the control groups. However, the histological images showed no significant differences between the groups. In the discussion, it was noted that the injection of Bisphenol F and Melatonin together increased bone hardness, suggesting that Bisphenol F and Bisphenol S may mitigate the negative effects of melatonin on bone. We attributed the absence of histological differences to the male gender of the studied rats and previous exposure considerations. This study shows that Melatonin can reduce Bisphenol F and Bisphenol S′ rapid adjustment effects and increase bone elasticity. The side effects of Bisphenol F and S, as well as the prophylactic effects of Melatonin, can be observed and improved by carefully adjusting the duration, dose, and gender selection.</p></div>","PeriodicalId":50974,"journal":{"name":"Annals of Anatomy-Anatomischer Anzeiger","volume":"256 ","pages":"Article 152314"},"PeriodicalIF":2.0000,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Melatonin's protective role against Bisphenol F and S-induced skeletal damage: A morphometric and histological study in rat\",\"authors\":\"Firuze Turker Yavas ,&nbsp;Figen Sevil Kilimci ,&nbsp;Ayse Nur Akkoc ,&nbsp;Hande Sultan Sahiner ,&nbsp;Özge Bardakci Yilmaz\",\"doi\":\"10.1016/j.aanat.2024.152314\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This study aimed to evaluate the potential effects of Bisphenol F and S exposure on the skeletal structures of Sprague-Dawley rats. Given the increasing concern about the potential endocrine-disrupting effects of Bisphenol analogs on bone health, this research sought to elucidate their impact in conjunction with Melatonin. Using 80 male Sprague Dawley rats, bones were subjected to a 3-point bending test to assess mechanical properties, and histopathological evaluation was conducted after fixation and decalcification. Statistical analysis was performed using SPSS. The results of the mechanical tests revealed significant differences in deformation and elastic modulus values between groups treated with Bisphenol F+Melatonin and Bisphenol S+Melatonin compared to the control groups. However, the histological images showed no significant differences between the groups. In the discussion, it was noted that the injection of Bisphenol F and Melatonin together increased bone hardness, suggesting that Bisphenol F and Bisphenol S may mitigate the negative effects of melatonin on bone. We attributed the absence of histological differences to the male gender of the studied rats and previous exposure considerations. This study shows that Melatonin can reduce Bisphenol F and Bisphenol S′ rapid adjustment effects and increase bone elasticity. The side effects of Bisphenol F and S, as well as the prophylactic effects of Melatonin, can be observed and improved by carefully adjusting the duration, dose, and gender selection.</p></div>\",\"PeriodicalId\":50974,\"journal\":{\"name\":\"Annals of Anatomy-Anatomischer Anzeiger\",\"volume\":\"256 \",\"pages\":\"Article 152314\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Anatomy-Anatomischer Anzeiger\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0940960224001067\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ANATOMY & MORPHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Anatomy-Anatomischer Anzeiger","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0940960224001067","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

本研究旨在评估接触双酚 F 和 S 对 Sprague-Dawley 大鼠骨骼结构的潜在影响。鉴于人们越来越关注双酚类似物对骨骼健康的潜在内分泌干扰作用,本研究试图结合褪黑素来阐明其影响。使用 80 只雄性 Sprague Dawley 大鼠,对骨骼进行三点弯曲测试,以评估其机械性能,并在固定和脱钙后进行组织病理学评估。使用 SPSS 进行了统计分析。力学测试结果表明,与对照组相比,使用双酚 F+ 褪黑激素和双酚 S+ 褪黑激素处理的各组在变形和弹性模量值方面存在显著差异。然而,组织学图像显示各组之间没有明显差异。讨论中指出,同时注射双酚 F 和褪黑素可增加骨硬度,这表明双酚 F 和双酚 S 可减轻褪黑素对骨骼的负面影响。我们认为,组织学上没有差异的原因是研究大鼠的性别为雄性,以及以前接触过褪黑激素。这项研究表明,褪黑素可以减轻双酚 F 和双酚 S 的快速调节作用,增加骨骼弹性。通过仔细调整持续时间、剂量和性别选择,可以观察和改善双酚 F 和双酚 S 的副作用以及褪黑素的预防作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Melatonin's protective role against Bisphenol F and S-induced skeletal damage: A morphometric and histological study in rat

This study aimed to evaluate the potential effects of Bisphenol F and S exposure on the skeletal structures of Sprague-Dawley rats. Given the increasing concern about the potential endocrine-disrupting effects of Bisphenol analogs on bone health, this research sought to elucidate their impact in conjunction with Melatonin. Using 80 male Sprague Dawley rats, bones were subjected to a 3-point bending test to assess mechanical properties, and histopathological evaluation was conducted after fixation and decalcification. Statistical analysis was performed using SPSS. The results of the mechanical tests revealed significant differences in deformation and elastic modulus values between groups treated with Bisphenol F+Melatonin and Bisphenol S+Melatonin compared to the control groups. However, the histological images showed no significant differences between the groups. In the discussion, it was noted that the injection of Bisphenol F and Melatonin together increased bone hardness, suggesting that Bisphenol F and Bisphenol S may mitigate the negative effects of melatonin on bone. We attributed the absence of histological differences to the male gender of the studied rats and previous exposure considerations. This study shows that Melatonin can reduce Bisphenol F and Bisphenol S′ rapid adjustment effects and increase bone elasticity. The side effects of Bisphenol F and S, as well as the prophylactic effects of Melatonin, can be observed and improved by carefully adjusting the duration, dose, and gender selection.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Annals of Anatomy-Anatomischer Anzeiger
Annals of Anatomy-Anatomischer Anzeiger 医学-解剖学与形态学
CiteScore
4.40
自引率
22.70%
发文量
137
审稿时长
33 days
期刊介绍: Annals of Anatomy publish peer reviewed original articles as well as brief review articles. The journal is open to original papers covering a link between anatomy and areas such as •molecular biology, •cell biology •reproductive biology •immunobiology •developmental biology, neurobiology •embryology as well as •neuroanatomy •neuroimmunology •clinical anatomy •comparative anatomy •modern imaging techniques •evolution, and especially also •aging
期刊最新文献
Implementing 3D printing and extended reality in anatomy education: Organization, evolution, and assessment of an innovative teaching program in an undergraduate medical school in the Netherlands Visible Human Project based applications can prompt integrating cross-sectional anatomy into the medical school curriculum when combined with radiological modalities: A three-year cross-sectional observational study Geometric morphometric analysis of plastinated brain sections using computer-based methods: Evaluating shrinkage and shape changes Advances in upper urinary tract anatomy through imaging techniques How to deal with the variability of peripheral nerve lesion patterns after inguinal herniotomy? A descriptive approach for a new terminology in clinical practice
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1