探索褪黑激素对镍诱导的左侧海马神经毒性的神经保护作用

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biometals Pub Date : 2024-07-26 DOI:10.1007/s10534-024-00618-w
Mohamed Yassine El Brouzi, Mouloud Lamtai, Nada Fath, Ayoub Rezqaoui, Oussama Zghari, Abdelghafour El Hamzaoui, Laila Ibouzine-Dine, Aboubaker El Hessni, Abdelhalem Mesfioui
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摘要

以往的研究表明,海马区是记忆和认知功能的关键区域,特别容易受到重金属暴露的不利影响。镍(Ni)是一种神经毒剂,主要会诱发氧化应激,而氧化应激过程会导致细胞损伤,进而影响神经功能。褪黑激素的抗氧化特性是预防镍的不良影响的一个很有前景的选择,特别是通过保护细胞免受氧化应激和相关损伤。在研究褪黑素对镍诱导的神经毒性的潜在神经保护作用时,我们选择在大鼠左侧海马内注射镍后,通过腹腔注射褪黑素。通过这种方法,我们可以有针对性地研究褪黑激素对镍的神经毒性效应的影响,尤其是在海马这一关键区域。在本研究中,我们证实褪黑素能有效降低乳酸脱氢酶水平,并保护镍暴露海马组织中的抗氧化酶活性。褪黑素还能缓解超氧化物歧化酶和过氧化氢酶活性的下降。另一方面,褪黑素可通过减少镍诱导的活性氧的过量产生而直接发挥作用。这两种潜在的作用机制可能是造成我们的研究中观察到的镍对行为改变产生不利影响的原因。这项研究为褪黑激素减轻镍对大脑,特别是海马区的有害影响提供了重要的见解,表明它可能对治疗与镍暴露有关的神经系统疾病具有重要意义。
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Exploring the neuroprotective role of melatonin against nickel-induced neurotoxicity in the left hippocampus.

Previous studies have demonstrated that the hippocampus, a crucial region for memory and cognitive functions, is particularly vulnerable to adverse effects of exposure to heavy metals. Nickel (Ni) is a neurotoxic agent that, primarily induces oxidative stress, a process known to contribute to cellular damage, which consequently affects neurological functions. The antioxidant properties of melatonin are a promising option for preventing the adverse effects of Ni, especially by protecting cells against oxidative stress and related damage. In our investigation of the potential neuroprotective effects of melatonin against Ni-induced neurotoxicity, we chose to administer melatonin through intraperitoneal injection in rats following an intrahippocampal injection of Ni into the left hippocampus. This approach allows us a targeted investigation into the influence of melatonin on the neurotoxic effects of Ni, particularly within the crucial context of the hippocampus. In the present study, we demonstrated that melatonin efficiency reduced lactate dehydrogenase level, and preserved antioxidant enzyme activities in Ni-exposed hippocampal tissue. It also mitigated the decline in superoxide dismutase and catalase activities. On the other hand, melatonin could act directly by reducing reactive oxygen species Ni-induced overproduction. Taking to gather these two potential mechanisms of action could be responsible for the adverse effect of Ni on the behavioral alteration observed in our study. This study provides significant insights into the potential of melatonin to mitigate the detrimental effects of Ni on the brain, particularly into the hippocampal region, suggesting its possible implications for the treatment of neurological disorders related to Ni exposure.

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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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