针对原发性脊柱关节炎和纤维肌痛并发症制定的标准化患者报告结果的性能。

IF 4.9 2区 医学 Q1 Medicine Arthritis Research & Therapy Pub Date : 2024-07-26 DOI:10.1186/s13075-024-03365-y
Styliani Tsiami, Piet Dukatz, Maria Gkelaki, Philipp Sewerin, Uta Kiltz, Xenofon Baraliakos
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引用次数: 0

摘要

背景:脊柱关节炎(SpA)和纤维肌痛(FM)患者会出现全身疼痛。目前尚未系统研究纤维肌痛对 SpA PRO 验证的影响:研究针对无慢性炎症性风湿病的原发性(p)纤维肌痛患者与无和伴有(c)纤维肌痛的 SpA 患者的 PROs 表现:方法:前瞻性地纳入患有原发性 FM、axSpA 或 PsA 且有适应治疗指征的患者。对标准化的PROs进行了评估:BASDAI、ASDAS-CRP、DAPSA、患者总体评估、BASFI、LEI、MASES、SPARCC 肌腱炎评分和 FIQ:共纳入 300 名患者(100/诊断)。除 ASDAS-CRP(FM 为 3.3 ± 0.6,axSpA 为 3.1 ± 1.0)和低腰椎晨僵持续时间外,pFM 患者在所有评估中的得分均明显高于 axSpA 或 PsA 患者。仅对女性患者进行的子分析也发现了类似的结果。此外,axSpA + 或 PsA + 患者与 pFM 患者没有差异,而 FM、axSpA + 和 PsA + 患者几乎所有 FIQ 项目的得分都明显高于 axSpA- 或 PsA- 患者:结论:最初为 axSpA 或 PsA 制定的 PROs 需要在有无 cFM 的情况下进行不同的解释。ASDAS-CRP和腰椎晨僵持续时间不受cFM的影响。FM特异性问卷也显示,有cFM的SpA患者得分较高,而没有cFM的患者得分则不高。
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Performance of standardized patient reported outcomes developed for spondyloarthritis in primary and concomitant forms of fibromyalgia.

Background: In spondyloarthritides (SpA) and fibromyalgia (FM), patients suffer from generalized pain. The impact of FM on PRO validated in SpA has not been systematically studied.

Objective: Study the performance of PROs developed for SpA in patients with primary (p) FM without chronic inflammatory-rheumatic disease vs. SpA without and with concomitant (c) FM.

Methods: Patients with pFM, axSpA or PsA and indication for treatment adaptation were prospectively included. Standardized PROs were assessed: BASDAI, ASDAS-CRP, DAPSA, patient´s global assessment, BASFI, LEI, MASES, SPARCC Enthesitis Score and FIQ.

Results: 300 patients were included (100/diagnosis). More males were found in axSpA vs. PsA and pFM group (67, 33 and 2/100, respectively), while 12 axSpA (axSpA+) and 16 PsA (PsA+) patients had cFM. pFM patients showed significantly higher scores in all assessments vs. axSpA or PsA, with exception of ASDAS-CRP (3.3 ± 0.6 in FM vs. 3.1 ± 1.0 in axSpA) and duration of low lumbar morning stiffness. Similar results were also found in the subanalysis of female patients only. In addition, patients with axSpA + or PsA + showed no differences to patients with pFM, while significantly higher scores were found for FM, axSpA + and PsA + for almost all FIQ items compared to axSpA- or PsA-.

Conclusions: PROs originally developed for axSpA or PsA need to be interpreted differently in the presence or absence of cFM. ASDAS-CRP and duration of lumbar morning stiffness were not affected by cFM. FM-specific questionnaires also showed high scores in patients with SpA with cFM but not in those without.

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来源期刊
CiteScore
8.60
自引率
2.00%
发文量
261
审稿时长
14 weeks
期刊介绍: Established in 1999, Arthritis Research and Therapy is an international, open access, peer-reviewed journal, publishing original articles in the area of musculoskeletal research and therapy as well as, reviews, commentaries and reports. A major focus of the journal is on the immunologic processes leading to inflammation, damage and repair as they relate to autoimmune rheumatic and musculoskeletal conditions, and which inform the translation of this knowledge into advances in clinical care. Original basic, translational and clinical research is considered for publication along with results of early and late phase therapeutic trials, especially as they pertain to the underpinning science that informs clinical observations in interventional studies.
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