Pub Date : 2026-02-09DOI: 10.1186/s13075-025-03727-0
Laura Reguilón, Jesús H Gómez, Salvador Carrillo-Tornel, Encarnación Saiz, María F Pina, Miriam Guzmán-Almansa, Nuria García-Barberá, Pedro J Guijarro-Carrillo, Ignacio Hervés, Juana M Plasencia, María T Herranz, María L Lozano, Carlos Pérez-Sánchez, Chary López-Pedrera, Constantino Martínez, Rocío González-Conejero
{"title":"Subclinical atherosclerosis in rheumatoid arthritis is driven by MicroRNA polymorphisms and NETosis.","authors":"Laura Reguilón, Jesús H Gómez, Salvador Carrillo-Tornel, Encarnación Saiz, María F Pina, Miriam Guzmán-Almansa, Nuria García-Barberá, Pedro J Guijarro-Carrillo, Ignacio Hervés, Juana M Plasencia, María T Herranz, María L Lozano, Carlos Pérez-Sánchez, Chary López-Pedrera, Constantino Martínez, Rocío González-Conejero","doi":"10.1186/s13075-025-03727-0","DOIUrl":"https://doi.org/10.1186/s13075-025-03727-0","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-07DOI: 10.1186/s13075-026-03757-2
Ashley M Potter, Lindsey H Burton, Kelly S Santangelo, Tara M Nordgren, Katie J Sikes
{"title":"Modulation of inflammatory pathways by omega-3 fatty acids in knee joint health for the management of post-traumatic osteoarthritis: a review.","authors":"Ashley M Potter, Lindsey H Burton, Kelly S Santangelo, Tara M Nordgren, Katie J Sikes","doi":"10.1186/s13075-026-03757-2","DOIUrl":"https://doi.org/10.1186/s13075-026-03757-2","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146136984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Patients with rheumatoid arthritis (RA) are at a higher risk for sarcopenia than the general population. Exercise therapy can improve muscle strength in older adults; however, its efficacy in older patients with RA has not been fully established. This study aimed to evaluate the efficacy of a personalized exercise program on physical function in older patients with RA at high risk for sarcopenia.
Methods: A single-centre, parallel-group, two-arm, superiority randomized controlled trial was conducted in patients with RA aged 60-85 years who were at risk of sarcopenia. The intervention group (n = 69) underwent a 16-week personalized exercise program in addition to nutritional guidance and standard care, whereas the control group (n = 65) received only nutritional guidance and standard care. The primary outcome was the change in the total Short Physical Performance Battery (SPPB) scores from baseline to week 16.
Results: A total of 140 patients were randomized. Of these, 134 initiated the assigned intervention. There was a 0.2-point difference in SPPB total score from baseline to week 16 between the intervention group (+ 0.4 points) and the control group (+ 0.2 points); 95% confidence interval: -0.1 to 0.5; p = 0.206. Regarding the secondary outcomes at week 16, there was a tendency for improvement in the chair-stand test, grip strength, and the mental component score.
Conclusion: The 16-week personalized exercise therapy did not improve the total SPPB scores. However, the intervention may improve standing ability, grip strength, and mental health-related quality of life in older patients with RA at high risk of sarcopenia.
Trial registration: This study was registered with UMINCTR (trial number: UMIN000044930).
{"title":"Effects of a personalized exercise program on physical function in older patients with rheumatoid arthritis at high risk of sarcopenia: results of a randomized controlled trial.","authors":"Mie Torii, Akira Onishi, Ryuji Uozumi, Yu Hidaka, Hideo Onizawa, Takayuki Fujii, Koichi Murata, Kosaku Murakami, Masao Tanaka, Yohei Oshima, Hiroki Tanaka, Yuki Urai, Kyosuke Tanigawa, Hiroyuki Yoshitomi, Hideaki Tsuji, Mirei Shirakashi, Ryosuke Hiwa, Ran Nakashima, Kazuko Nin, Ayae Kinoshita, Shuichi Matsuda, Akio Morinobu, Hidenori Arai, Motomu Hashimoto","doi":"10.1186/s13075-026-03751-8","DOIUrl":"https://doi.org/10.1186/s13075-026-03751-8","url":null,"abstract":"<p><strong>Background: </strong>Patients with rheumatoid arthritis (RA) are at a higher risk for sarcopenia than the general population. Exercise therapy can improve muscle strength in older adults; however, its efficacy in older patients with RA has not been fully established. This study aimed to evaluate the efficacy of a personalized exercise program on physical function in older patients with RA at high risk for sarcopenia.</p><p><strong>Methods: </strong>A single-centre, parallel-group, two-arm, superiority randomized controlled trial was conducted in patients with RA aged 60-85 years who were at risk of sarcopenia. The intervention group (n = 69) underwent a 16-week personalized exercise program in addition to nutritional guidance and standard care, whereas the control group (n = 65) received only nutritional guidance and standard care. The primary outcome was the change in the total Short Physical Performance Battery (SPPB) scores from baseline to week 16.</p><p><strong>Results: </strong>A total of 140 patients were randomized. Of these, 134 initiated the assigned intervention. There was a 0.2-point difference in SPPB total score from baseline to week 16 between the intervention group (+ 0.4 points) and the control group (+ 0.2 points); 95% confidence interval: -0.1 to 0.5; p = 0.206. Regarding the secondary outcomes at week 16, there was a tendency for improvement in the chair-stand test, grip strength, and the mental component score.</p><p><strong>Conclusion: </strong>The 16-week personalized exercise therapy did not improve the total SPPB scores. However, the intervention may improve standing ability, grip strength, and mental health-related quality of life in older patients with RA at high risk of sarcopenia.</p><p><strong>Trial registration: </strong>This study was registered with UMINCTR (trial number: UMIN000044930).</p>","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1186/s13075-026-03744-7
Olivia Solomon, Caroline Shiboski, Kimberly E Taylor, Hong Quach, Diana Quach, Lisa F Barcellos, Lindsey A Criswell
{"title":"Sjögren's patient subgroups identified through whole genome DNA methylation profiling.","authors":"Olivia Solomon, Caroline Shiboski, Kimberly E Taylor, Hong Quach, Diana Quach, Lisa F Barcellos, Lindsey A Criswell","doi":"10.1186/s13075-026-03744-7","DOIUrl":"https://doi.org/10.1186/s13075-026-03744-7","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reassessing the role of watchful waiting strategy for IgG4-related disease: a real-world study.","authors":"Chengqian Liao, Yanli Huang, Guilian Shang, Wei Sun, Shaozhe Cai, Lingli Dong","doi":"10.1186/s13075-026-03743-8","DOIUrl":"https://doi.org/10.1186/s13075-026-03743-8","url":null,"abstract":"","PeriodicalId":8419,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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