评估社区环境中人体呼出气体和室内空气中的四氯乙烯 (PCE) 及其降解产物。

IF 3.7 4区 医学 Q1 BIOCHEMICAL RESEARCH METHODS Journal of breath research Pub Date : 2024-08-08 DOI:10.1088/1752-7163/ad67fd
Jung Hyun Lee, Alaina K Bryant, Marwan Alajlouni, Brandon E Boor, Antonios Tasoglou, Sa Liu
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引用次数: 0

摘要

四氯乙烯(PCE)是一种广泛应用于工业领域的挥发性化学品,包括干洗和金属脱脂。接触 PCE 可能会对工人以及污染场地附近的社区造成严重的健康风险。对健康的不利影响不仅来自于 PCE,还来自于 PCE 的降解产物,如三氯乙烯 (TCE) 和氯乙烯 (VC)。PCE、TCE 和 VC 可污染水、土壤和空气,导致通过多种途径(包括吸入、摄入和皮肤接触)接触这些物质。这项研究的重点是印第安纳州马丁斯维尔的一个社区环境,这是美国中西部的一个工人阶级社区,由于存在多个污染点(指 "羽流"),包括一个超级基金场地,该社区受到了广泛的 PCE 污染。利用质子转移反应飞行时间质谱法(PTR-TOF-MS),测量了羽流区内外 73 位居民呼出气体中的 PCE、TCE 和 VC 浓度。在 66 个样本中检测到了 PCE,在 26 个样本中检测到了 TCE,在 68 个样本中检测到了 VC。我们的研究结果表明,这些化合物在呼出气体和室内空气中的浓度之间存在明显的正相关关系(皮尔逊相关系数:PCE = 0.75,TCE = 0.71,VC = 0.89)。这项研究证实,在一项社区接触调查中,呼出的气体中含有五氯乙烯及其降解产物,这证明了利用呼出气体分析监测环境污染物接触情况的潜力。这项研究表明,在社区调查中利用 PTR-TOF-MS 测量呼出气体和室内空气中的五氯乙烯及其降解产物是可行的。
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Evaluation of tetrachloroethylene (PCE) and its degradation products in human exhaled breath and indoor air in a community setting.

Tetrachloroethylene (PCE) is a widely utilized volatile chemical in industrial applications, including dry cleaning and metal degreasing. Exposure to PCE potentially presents a significant health risk to workers as well as communities near contamination sites. Adverse health effects arise not only from PCE, but also from PCE degradation products, such as trichloroethylene (TCE) and vinyl chloride (VC). PCE, TCE, and VC can contaminate water, soil, and air, leading to exposure through multiple pathways, including inhalation, ingestion, and dermal contact. This study focused on a community setting in Martinsville, Indiana, a working-class Midwestern community in the United States, where extensive PCE contamination has occurred due to multiple contamination sites (referring to 'plumes'), including a Superfund site. Utilizing proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS), PCE, TCE, and VC concentrations were measured in the exhaled breath of 73 residents from both within and outside the plume areas. PCE was detected in 66 samples, TCE in 26 samples, and VC in 68 samples. Our results revealed a significant positive correlation between the concentrations of these compounds in exhaled breath and indoor air (Pearson correlation coefficients: PCE = 0.75, TCE = 0.71, and VC = 0.89). This study confirms the presence of PCE and its degradation products in exhaled breath in a community exposure investigation, demonstrating the potential of using exhaled breath analysis in monitoring exposure to environmental contaminants. This study showed the feasibility of utilizing PTR-TOF-MS in community investigations to assess exposure to PCE and its degradation products by measuring these compounds in exhaled breath and indoor air.

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来源期刊
Journal of breath research
Journal of breath research BIOCHEMICAL RESEARCH METHODS-RESPIRATORY SYSTEM
CiteScore
7.60
自引率
21.10%
发文量
49
审稿时长
>12 weeks
期刊介绍: Journal of Breath Research is dedicated to all aspects of scientific breath research. The traditional focus is on analysis of volatile compounds and aerosols in exhaled breath for the investigation of exogenous exposures, metabolism, toxicology, health status and the diagnosis of disease and breath odours. The journal also welcomes other breath-related topics. Typical areas of interest include: Big laboratory instrumentation: describing new state-of-the-art analytical instrumentation capable of performing high-resolution discovery and targeted breath research; exploiting complex technologies drawn from other areas of biochemistry and genetics for breath research. Engineering solutions: developing new breath sampling technologies for condensate and aerosols, for chemical and optical sensors, for extraction and sample preparation methods, for automation and standardization, and for multiplex analyses to preserve the breath matrix and facilitating analytical throughput. Measure exhaled constituents (e.g. CO2, acetone, isoprene) as markers of human presence or mitigate such contaminants in enclosed environments. Human and animal in vivo studies: decoding the ''breath exposome'', implementing exposure and intervention studies, performing cross-sectional and case-control research, assaying immune and inflammatory response, and testing mammalian host response to infections and exogenous exposures to develop information directly applicable to systems biology. Studying inhalation toxicology; inhaled breath as a source of internal dose; resultant blood, breath and urinary biomarkers linked to inhalation pathway. Cellular and molecular level in vitro studies. Clinical, pharmacological and forensic applications. Mathematical, statistical and graphical data interpretation.
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