随访 10 年后,轴性脊柱关节炎结构性结果变化的敏感性。数据来自DESIR队列。

IF 5.1 2区 医学 Q1 RHEUMATOLOGY RMD Open Pub Date : 2024-07-25 DOI:10.1136/rmdopen-2024-004400
Clementina López-Medina, Anna Molto, Alexandre Sepriano, Sofia Ramiro, Anne Tournadre, Maxime Dougados
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引用次数: 0

摘要

目的评估轴性脊柱关节炎(axSpA)患者随访10年后结构成像结果变化的敏感性:方法:纳入 Devenir des Spondyloarthropathies Indifferénciées Récentes 队列中的 axSpA 患者。在基线和1年、2年、5年和10年时拍摄骶髂关节(SIJ)和脊柱的X光片和磁共振成像。使用广义估计方程模型分析了每种结构性结果的年变化率,包括所有在≥1个阅读波次中≥1个阅读器中得分≥1分的患者,使用时间(年)作为解释变量,并对阅读器和波次进行调整。所有结果都进行了标准化处理,并计算了相对标准化变化率(即结果的标准化变化率除以参考结果的变化率):共纳入 659 名患者(46% 为男性,平均年龄为 33.6 岁)。对SIJ变化(MRI和X光片)最敏感的结果是在特定时间点出现≥3个脂肪病变,以修改后的纽约标准为参考,每年的相对标准化变化率为5.28。同样,对脊柱变化(MRI和X光片)最敏感的结果是修改后的斯托克强直性脊柱炎脊柱评分(mSASSS;每年的相对标准化变化率为1.76),以≥1个联合骨赘为参考:结论:与放射学结果相比,MRI 对 SIJ 结构变化(即脂肪病变)的敏感性更高。相反,即使与脊柱的 MRI 相比,mSASSS 仍是最敏感的方法。
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Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort.

Objective: To evaluate the sensitivity to change in structural imaging outcomes over 10 years of follow-up in patients with axial spondyloarthritis (axSpA).

Methods: Patients with axSpA from the Devenir des Spondyloarthropathies Indifferénciées Récentes cohort were included. Radiographs and MRIs of the sacroiliac joints (SIJ) and spine were obtained at baseline and at 1, 2, 5 and 10 years. The yearly rate of change of each structural outcome was analysed using generalised estimating equation models, including all patients with ≥1 score from ≥1 reader from ≥1 reading wave, using the time (years) as an explanatory variable and adjusting for reader and wave. All outcomes were standardised, and the relative standardised rate of change was calculated (ie, the standardised rate of an outcome divided by the rate of a reference outcome).

Results: A total of 659 patients (46% males and mean age 33.6 years) were included. The most sensitive outcome to change in the SIJ (both MRI and radiographs) was the presence of ≥3 fatty lesions at a specific timepoint, with a relative standardised rate of change per year of 5.28 using the modified New York criteria as reference.Similarly, the most sensitive to change (in both MRI and radiographs) outcome in the spine was the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS; relative standardised yearly change 1.76) using ≥1 syndesmophyte as reference.

Conclusion: MRI structural outcomes in the SIJ (ie, fatty lesions) are more sensitive to change than radiographic outcomes. Conversely, the mSASSS remains the most sensitive method, even when compared with MRI of the spine.

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来源期刊
RMD Open
RMD Open RHEUMATOLOGY-
CiteScore
7.30
自引率
6.50%
发文量
205
审稿时长
14 weeks
期刊介绍: RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.
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