Frank Sebastian Fröschen, Pia Maria Kitkowski, Andreas Christian Strauß, Ernst Molitor, Gunnar Thorben Rembert Hischebeth, Alexander Franz
{"title":"脊柱盘炎症患者的微生物学特征","authors":"Frank Sebastian Fröschen, Pia Maria Kitkowski, Andreas Christian Strauß, Ernst Molitor, Gunnar Thorben Rembert Hischebeth, Alexander Franz","doi":"10.3390/antibiotics13070671","DOIUrl":null,"url":null,"abstract":"<p><p>Spondylodiscitis is a severe spinal infection that requires an effective antibiotic treatment. Therefore, we sought to analyse the causative pathogens from intraoperative specimen in patients with spondylodiscitis and a need for surgery. To this end, we performed a retrospective study of all patients with spondylodiscitis and a need for operative treatment admitted to our hospital between January 2020 and December 2022. A total of 114 cases with spondylodiscitis were identified. A total of 120 different pathogens were detected. Overall, 76.7% of those microorganisms were Gram-positive bacteria. The most common causative pathogen was <i>Staphylococcus aureus</i> (<i>n</i> = 32; 26.6%), followed by coagulase-negative staphylococci (<i>n</i> = 28; 23.4%), of which <i>Staphylococcus epidermidis</i> (<i>n</i> = 18; 15%) was the most frequently detected, as well as enterococci (<i>n</i> = 10; 8.4%) and <i>Streptococcus</i> spp. (<i>n</i> = 11; 9.2%). Moreover, 19.1% (<i>n</i> = 22) and 3.4% (<i>n</i> = 4) of all detected isolates were Gram-negative pathogens or fungi, respectively. Overall, 42.8% of all coagulase-negative staphylococci were oxacillin-resistant, while none of them were vancomycin-resistant. In summary, 50% of the pathogens could be identified as staphylococci. The results of our study highlight the important burden of oxacillin-resistant Gram-positive bacteria as an aetiological cause of spondylodiscitis, providing a relevant finding for antimicrobial stewardship programmes.</p>","PeriodicalId":54246,"journal":{"name":"Antibiotics-Basel","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11274050/pdf/","citationCount":"0","resultStr":"{\"title\":\"Microbiological Profiles of Patients with Spondylodiscitis.\",\"authors\":\"Frank Sebastian Fröschen, Pia Maria Kitkowski, Andreas Christian Strauß, Ernst Molitor, Gunnar Thorben Rembert Hischebeth, Alexander Franz\",\"doi\":\"10.3390/antibiotics13070671\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Spondylodiscitis is a severe spinal infection that requires an effective antibiotic treatment. Therefore, we sought to analyse the causative pathogens from intraoperative specimen in patients with spondylodiscitis and a need for surgery. To this end, we performed a retrospective study of all patients with spondylodiscitis and a need for operative treatment admitted to our hospital between January 2020 and December 2022. A total of 114 cases with spondylodiscitis were identified. A total of 120 different pathogens were detected. Overall, 76.7% of those microorganisms were Gram-positive bacteria. The most common causative pathogen was <i>Staphylococcus aureus</i> (<i>n</i> = 32; 26.6%), followed by coagulase-negative staphylococci (<i>n</i> = 28; 23.4%), of which <i>Staphylococcus epidermidis</i> (<i>n</i> = 18; 15%) was the most frequently detected, as well as enterococci (<i>n</i> = 10; 8.4%) and <i>Streptococcus</i> spp. (<i>n</i> = 11; 9.2%). Moreover, 19.1% (<i>n</i> = 22) and 3.4% (<i>n</i> = 4) of all detected isolates were Gram-negative pathogens or fungi, respectively. Overall, 42.8% of all coagulase-negative staphylococci were oxacillin-resistant, while none of them were vancomycin-resistant. In summary, 50% of the pathogens could be identified as staphylococci. 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Microbiological Profiles of Patients with Spondylodiscitis.
Spondylodiscitis is a severe spinal infection that requires an effective antibiotic treatment. Therefore, we sought to analyse the causative pathogens from intraoperative specimen in patients with spondylodiscitis and a need for surgery. To this end, we performed a retrospective study of all patients with spondylodiscitis and a need for operative treatment admitted to our hospital between January 2020 and December 2022. A total of 114 cases with spondylodiscitis were identified. A total of 120 different pathogens were detected. Overall, 76.7% of those microorganisms were Gram-positive bacteria. The most common causative pathogen was Staphylococcus aureus (n = 32; 26.6%), followed by coagulase-negative staphylococci (n = 28; 23.4%), of which Staphylococcus epidermidis (n = 18; 15%) was the most frequently detected, as well as enterococci (n = 10; 8.4%) and Streptococcus spp. (n = 11; 9.2%). Moreover, 19.1% (n = 22) and 3.4% (n = 4) of all detected isolates were Gram-negative pathogens or fungi, respectively. Overall, 42.8% of all coagulase-negative staphylococci were oxacillin-resistant, while none of them were vancomycin-resistant. In summary, 50% of the pathogens could be identified as staphylococci. The results of our study highlight the important burden of oxacillin-resistant Gram-positive bacteria as an aetiological cause of spondylodiscitis, providing a relevant finding for antimicrobial stewardship programmes.
Antibiotics-BaselPharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
7.30
自引率
14.60%
发文量
1547
审稿时长
11 weeks
期刊介绍:
Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.