Polymorphism of Antioxidant Genes and Overweight in Children

Abstract—

Oxidative stress is one of the components of the pathological process leading to the development of obesity. The level of formation of free radical products is controlled by the antioxidant system. Antioxidant gene polymorphism influences the level and/or activity of the encoded enzymes. The purpose of this work was to investigate the association of SNP in the genes of the antioxidant system with the risk of overweight in children and adolescents. The material for the study were DNA samples from 279 overweight children and 131 children from the control group. Genotyping was performed for rs6721961 (–617G>T) NFE2L2, rs4998557 (7958G>A) SOD1, rs4880 (47C>T Ala16Val) SOD2, rs1001179 (–262C>T) CAT, rs713041 (718C>T) GPX4, rs662 (Gln192Arg) PON1. It has been shown that the –617GT genotype (rs6721961) NFE2L2 is associated with a decreased risk of overweight in children. An increased risk of developing overweight was detected for heterozygotes –262CT for rs1001179 CAT and the –262T allele. As a result of the analysis of intergenic interactions, a 6-locus genotype was identified that is associated with a reduced risk of overweight.