升主动脉中 TBX20 基因 5' 区域的甲基化水平在动脉粥样硬化和动脉瘤中呈相反方向变化

IF 0.6 4区生物学 Q4 GENETICS & HEREDITY Russian Journal of Genetics Pub Date : 2024-07-27 DOI:10.1134/s102279542470042x

Iu. A. Koroleva, I. A. Goncharova, A. A. Zarubin, S. A. Shipulina, A. A. Sleptsov, D. S. Panfilov, B. N. Kozlov, M. S. Nazarenko

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引用次数: 0

摘要

摘要我们发现，与升主动脉瘤患者主动脉扩张部分相比，动脉粥样硬化主动脉斑块组织中TBX20基因（7p14.2）5'区的5个CpG位点甲基化水平较低。利用 GEO 数据库，我们发现在主动脉夹层和主动脉粥样硬化中，chr7:35253926-35262250 区域的 DNA 甲基化水平变化方向相反。这些结果表明，主动脉粥样硬化和主动脉瘤的表观遗传调控都发生了改变。

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Methylation Levels in the 5' Region of the TBX20 Gene in the Ascending Aorta Change in Opposite Direction in Atherosclerosis and Aneurysm

Abstract

We found hypomethylation of five CpG sites in the 5' region of TBX20 gene (7p14.2) in the tissues of atherosclerotic aortic plaque compared to dilated part of aorta in patients with ascending aortic aneurysm. Using GEO database, we found that the DNA methylation level in the chr7:35253926-35262250 region changes in opposite direction in aortic dissection and aortic atherosclerosis. The results suggest an alteration in epigenetic regulation both in aortic atherosclerosis and aortic aneurysm.

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来源期刊

Russian Journal of Genetics 生物-遗传学

CiteScore

1.00

自引率

33.30%

发文量

126

审稿时长

1 months

期刊介绍： Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.