Microwave-assisted synthesis of 1,4-disubstituted 1,2,3-triazole derivatives utilizing NiO/Cu2O nano-photocatalyst
BACKGROUND
The main characteristic features of nickel–copper-catalyzed azide–alkyne click (Ni-CuAAC) reactions for production of 1,2,3-triazoles are regioselectivity and the reaction proceeding under mild conditions. The use of copper salts as catalysts often leads to challenges like contamination of the prepared triazoles. NiO/Cu2O nanocomposites (NCs) were utilized in Ni-CuAAC reactions as heterogeneous nanocatalysts to achieve the production of some 1,4-disubstituted 1,2,3-triazoles in high chemical yields under microwave irradiation.
RESULTS
The preparation of NiO/Cu2O NCs was performed through the coprecipitation of NiO nanoparticles on Cu2O surface. The prepared catalyst was used for catalyzing a reaction between benzoyl azides and phenylacetylene under optimized reaction conditions. The NiO/Cu2O NCs exhibited high catalytic activity compared to Cu2O nanoparticles. In addition, by utilizing ethanol–water as the solvent system under microwave irradiation, higher yields and efficient product separation were observed.
期刊介绍:
Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.