Mazin T. Alqhazo, Dianne F. Newbury, Ayat B. Rashaid
{"title":"儿童期口吃患者血浆中的硫胺素和组胺水平","authors":"Mazin T. Alqhazo, Dianne F. Newbury, Ayat B. Rashaid","doi":"10.1177/15257401241263321","DOIUrl":null,"url":null,"abstract":"This study aims to compare the concentrations of thiamine and histamine in the samples of 41 normal fluent speakers and 43 children who stutter. Blood samples were collected for the determination of thiamine and histamine using high-performance liquid chromatography coupled to ultraviolet detector (HPLC-UV). The results revealed a significantly lower level of thiamine in the stuttering group ( M = 29.9, SD = 15.6) compared with the control group ( M = 38, SD = 19.3, p = .02), and a significantly higher level of histamine in the stuttering group ( M = 20.5, SD = 6.5) compared with the control group ( M = 9.4, SD = 7.5, p ≤ .00). The results also indicated a significant negative correlation between severity scores and the level of histamine. The findings of the current study may provide further supporting information about the relationship between childhood-onset stuttering and some biological markers such as thiamine and histamine.","PeriodicalId":46403,"journal":{"name":"Communication Disorders Quarterly","volume":"41 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Plasma Levels of Thiamine and Histamine in Childhood-Onset Stuttering\",\"authors\":\"Mazin T. Alqhazo, Dianne F. Newbury, Ayat B. Rashaid\",\"doi\":\"10.1177/15257401241263321\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study aims to compare the concentrations of thiamine and histamine in the samples of 41 normal fluent speakers and 43 children who stutter. Blood samples were collected for the determination of thiamine and histamine using high-performance liquid chromatography coupled to ultraviolet detector (HPLC-UV). The results revealed a significantly lower level of thiamine in the stuttering group ( M = 29.9, SD = 15.6) compared with the control group ( M = 38, SD = 19.3, p = .02), and a significantly higher level of histamine in the stuttering group ( M = 20.5, SD = 6.5) compared with the control group ( M = 9.4, SD = 7.5, p ≤ .00). The results also indicated a significant negative correlation between severity scores and the level of histamine. The findings of the current study may provide further supporting information about the relationship between childhood-onset stuttering and some biological markers such as thiamine and histamine.\",\"PeriodicalId\":46403,\"journal\":{\"name\":\"Communication Disorders Quarterly\",\"volume\":\"41 1\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Communication Disorders Quarterly\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15257401241263321\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"REHABILITATION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Communication Disorders Quarterly","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15257401241263321","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"REHABILITATION","Score":null,"Total":0}
Plasma Levels of Thiamine and Histamine in Childhood-Onset Stuttering
This study aims to compare the concentrations of thiamine and histamine in the samples of 41 normal fluent speakers and 43 children who stutter. Blood samples were collected for the determination of thiamine and histamine using high-performance liquid chromatography coupled to ultraviolet detector (HPLC-UV). The results revealed a significantly lower level of thiamine in the stuttering group ( M = 29.9, SD = 15.6) compared with the control group ( M = 38, SD = 19.3, p = .02), and a significantly higher level of histamine in the stuttering group ( M = 20.5, SD = 6.5) compared with the control group ( M = 9.4, SD = 7.5, p ≤ .00). The results also indicated a significant negative correlation between severity scores and the level of histamine. The findings of the current study may provide further supporting information about the relationship between childhood-onset stuttering and some biological markers such as thiamine and histamine.
期刊介绍：
Articles for Communication Disorders Quarterly (CDQ) are accepted for review on a continual basis. The editor of CDQ welcomes submissions of previously unpublished applied and clinical research relating to typical and atypical communication across the lifespan. This includes assessment of and interventions for communicative disorders in infants, toddlers, young children, school-age children, youth, and adults. The readers of CDQ represent a breadth of viewpoints and professional interests, which is also reflected in the diversity of interests and expertise of the editorial board members. The journal is particularly of interest to speech–language pathologists and teachers of the deaf and hard of hearing. CDQ uses a masked peer review process for submissions.
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