{"title":"钼和钨的碘化物团簇是光动力灭活和治疗的理想药剂","authors":"M. A. Mikhailov, M. N. Sokolov","doi":"10.1007/s11172-024-4272-0","DOIUrl":null,"url":null,"abstract":"<p>Octahedral iodide clusters of molybdenum and tungsten [M<sub>6</sub>I<sub>8</sub>L<sub>6</sub>] are considered as promising components of new classes of luminescent materials. When excited with the light at a wavelength of ≤450 nm, the clusters form long-lived triplet states emitting red phosphorescence. This phosphorescence is deactivated in the presence of molecular oxygen to form singlet oxygen in a high yield. Due to the capability of photogenerating singlet oxygen, the [M<sub>6</sub>I<sub>8</sub>L<sub>6</sub>] clusters and related materials exhibit photoinduced cytotoxicity and bactericidal action. Universal methods developed to date make it possible to prepare cluster compounds with specified compositions and properties depending on ligand L. This review considers the prospects for developing drugs for antimicrobial photodynamic inactivation and photodynamic cancer therapy based on the [M<sub>6</sub>I<sub>8</sub>L<sub>6</sub>] clusters.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Iodide clusters of molybdenum and tungsten as promising agents for photodynamic inactivation and therapy\",\"authors\":\"M. A. Mikhailov, M. N. Sokolov\",\"doi\":\"10.1007/s11172-024-4272-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Octahedral iodide clusters of molybdenum and tungsten [M<sub>6</sub>I<sub>8</sub>L<sub>6</sub>] are considered as promising components of new classes of luminescent materials. When excited with the light at a wavelength of ≤450 nm, the clusters form long-lived triplet states emitting red phosphorescence. This phosphorescence is deactivated in the presence of molecular oxygen to form singlet oxygen in a high yield. Due to the capability of photogenerating singlet oxygen, the [M<sub>6</sub>I<sub>8</sub>L<sub>6</sub>] clusters and related materials exhibit photoinduced cytotoxicity and bactericidal action. Universal methods developed to date make it possible to prepare cluster compounds with specified compositions and properties depending on ligand L. This review considers the prospects for developing drugs for antimicrobial photodynamic inactivation and photodynamic cancer therapy based on the [M<sub>6</sub>I<sub>8</sub>L<sub>6</sub>] clusters.</p>\",\"PeriodicalId\":756,\"journal\":{\"name\":\"Russian Chemical Bulletin\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Chemical Bulletin\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s11172-024-4272-0\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s11172-024-4272-0","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Iodide clusters of molybdenum and tungsten as promising agents for photodynamic inactivation and therapy
Octahedral iodide clusters of molybdenum and tungsten [M6I8L6] are considered as promising components of new classes of luminescent materials. When excited with the light at a wavelength of ≤450 nm, the clusters form long-lived triplet states emitting red phosphorescence. This phosphorescence is deactivated in the presence of molecular oxygen to form singlet oxygen in a high yield. Due to the capability of photogenerating singlet oxygen, the [M6I8L6] clusters and related materials exhibit photoinduced cytotoxicity and bactericidal action. Universal methods developed to date make it possible to prepare cluster compounds with specified compositions and properties depending on ligand L. This review considers the prospects for developing drugs for antimicrobial photodynamic inactivation and photodynamic cancer therapy based on the [M6I8L6] clusters.
期刊介绍:
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.