Ya. K. Shtaitz, M. I. Valieva, E. D. Ladin, A. Rammohan, K. D. Krasnoperova, N. A. Belyaev, D. S. Kopchuk, G. V. Zyryanov, V. L. Rusinov
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Azetidine and cyclopropylamine in the “1,2,4-triazine” methodology for the synthesis of α-functionalized 2,2′-bipyridines
Functionalization of 3-(2-pyridyl)-1,2,4-triazines with small (aza)cyclic compounds (azetidine and cyclopropylamine) via nucleophilic ipso-substitution of the cyano group and subsequent transformation of the 1,2,4-triazine ring into pyridine one via the aza-Diels—Alder reaction were explored. The successful proceeding of such a transformation depended on the structure of the nucleophilic residue: both steps were successfully implemented upon using a cyclopropylamine derivative, while in the case of azetidine-containing 1,2,4-triazines, there was only the resinification of the reaction mass.
期刊介绍:
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.