二苯基氧化膦与乙炔基氨基酮的化学、区域和立体选择性无催化剂加成。合成 Z-二苯基磷酰(羰基氨基)烯酮

IF 1.7 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Russian Chemical Bulletin Pub Date : 2024-07-26 DOI:10.1007/s11172-024-4291-x
S. I. Verkhoturova, P. A. Volkov, I. A. Bidusenko, S. N. Arbuzova, S. V. Zinchenko, B. A. Trofimov
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引用次数: 0

摘要

二苯基氧化膦与 1,4-二甘氨酰-4-(organylamino)-alk-2-炔-1-酮在无催化剂的情况下进行化学、区域和立体选择性加成,得到新的 Z-3-二苯基磷酰-1,4-二甘氨酰-4-(organylamino)烷-2-烯-1-酮,收率高达 75%。合成的化合物有望用于有机合成和药物研究。
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Chemo-, regio-, and stereoselective catalyst-free addition of diphenylphosphine oxide to acetylenic amino ketones. Synthesis of Z-diphenylphosphoryl(organylamino)alkenones

Catalyst-free addition of diphenylphosphine oxide to 1,4-diorganyl-4-(organylamino)-alk-2-yn-1-ones proceeded chemo-, regio-, and stereoselectively to afford new Z-3-diphenylphosphoryl-1,4-diorganyl-4-(organylamino)alk-2-en-1-ones in up to 75% yield. The synthesized compounds are promising candidates for organic synthesis and pharmaceutical research.

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来源期刊
Russian Chemical Bulletin
Russian Chemical Bulletin 化学-化学综合
CiteScore
2.70
自引率
47.10%
发文量
257
审稿时长
3-8 weeks
期刊介绍: Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.
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