Satish Bhawsar, Mohammad Shaikh, Sanjeev Joshi, Amit Mishra, Laxmikant Pavase, Vijay Chavan, Amol Kale, Abhijeet K. Kayastha, Ravindra Yeole, Sachin Bhagwat, Mahesh Patel
{"title":"合成和评估新型双芳基噁唑烷酮类化合物，有效对抗革兰氏阳性细菌感染","authors":"Satish Bhawsar, Mohammad Shaikh, Sanjeev Joshi, Amit Mishra, Laxmikant Pavase, Vijay Chavan, Amol Kale, Abhijeet K. Kayastha, Ravindra Yeole, Sachin Bhagwat, Mahesh Patel","doi":"10.1007/s00044-024-03287-z","DOIUrl":null,"url":null,"abstract":"<div><p>Oxazolidinones are synthetic antibiotic class of compounds characterized by chemical structure, cyclic carbamate with ‘<i>S’</i> configuration of substituent at <i>C</i>-5 position. The synthesis of oxazolidinones has gained increasing interest due to their unique mechanism of action that assures high antibiotic efficiency and low susceptibility to resistance mechanisms. Biaryl oxazolidinones are second-generation oxazolidinone (e.g. Tedizolid) having potency against multidrug-resistant (MDR) gram-positive pathogens including <i>MRSA</i>, <i>VRE</i>, penicillin-resistant <i>S. pneumoniae</i> and linezolid-resistant strains. The current manuscript covers structure activity based synthesis of 21 oxazolidinone analogs prepared through various chemical modifications. These novel biaryl oxazolidinones are prepared with the objective to increase spectrum of activity against multidrug-resistant Gram-positive bacteria.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"33 10","pages":"1887 - 1896"},"PeriodicalIF":2.6000,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and evaluation of novel biaryl oxazolidinones effective against gram-positive bacterial infections\",\"authors\":\"Satish Bhawsar, Mohammad Shaikh, Sanjeev Joshi, Amit Mishra, Laxmikant Pavase, Vijay Chavan, Amol Kale, Abhijeet K. Kayastha, Ravindra Yeole, Sachin Bhagwat, Mahesh Patel\",\"doi\":\"10.1007/s00044-024-03287-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Oxazolidinones are synthetic antibiotic class of compounds characterized by chemical structure, cyclic carbamate with ‘<i>S’</i> configuration of substituent at <i>C</i>-5 position. The synthesis of oxazolidinones has gained increasing interest due to their unique mechanism of action that assures high antibiotic efficiency and low susceptibility to resistance mechanisms. Biaryl oxazolidinones are second-generation oxazolidinone (e.g. Tedizolid) having potency against multidrug-resistant (MDR) gram-positive pathogens including <i>MRSA</i>, <i>VRE</i>, penicillin-resistant <i>S. pneumoniae</i> and linezolid-resistant strains. The current manuscript covers structure activity based synthesis of 21 oxazolidinone analogs prepared through various chemical modifications. These novel biaryl oxazolidinones are prepared with the objective to increase spectrum of activity against multidrug-resistant Gram-positive bacteria.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":699,\"journal\":{\"name\":\"Medicinal Chemistry Research\",\"volume\":\"33 10\",\"pages\":\"1887 - 1896\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicinal Chemistry Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00044-024-03287-z\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinal Chemistry Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00044-024-03287-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Synthesis and evaluation of novel biaryl oxazolidinones effective against gram-positive bacterial infections
Oxazolidinones are synthetic antibiotic class of compounds characterized by chemical structure, cyclic carbamate with ‘S’ configuration of substituent at C-5 position. The synthesis of oxazolidinones has gained increasing interest due to their unique mechanism of action that assures high antibiotic efficiency and low susceptibility to resistance mechanisms. Biaryl oxazolidinones are second-generation oxazolidinone (e.g. Tedizolid) having potency against multidrug-resistant (MDR) gram-positive pathogens including MRSA, VRE, penicillin-resistant S. pneumoniae and linezolid-resistant strains. The current manuscript covers structure activity based synthesis of 21 oxazolidinone analogs prepared through various chemical modifications. These novel biaryl oxazolidinones are prepared with the objective to increase spectrum of activity against multidrug-resistant Gram-positive bacteria.
期刊介绍：
Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
