纤维环中的三维纤维图案可从椎体终板地形图中得出。

IF 3.4 3区 医学 Q1 ORTHOPEDICS JOR Spine Pub Date : 2024-07-25 DOI:10.1002/jsp2.1361
Ali Raza, Gwynneth T. Howell, Arthur J. Michalek
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引用次数: 0

摘要

简介:椎间盘(IVD)的纤维环(AF)由螺旋缠绕的胶原纤维同心层组成。了解这些薄片中胶原纤维取向的空间变化以及由此产生的材料各向异性对于预测完整 IVD 的机械行为至关重要:本研究以先前的一个模型为基础,该模型以椎体生长过程中纤维端点的路径无关位移为前提,通过少量与受试者无关的输入参数和从临床成像中获得的椎体终板地形图来预测完整的三维纤维环网络。为了对该模型进行评估,首先对牛尾椎间盘的中平面纤维方向进行了拟合,并通过偏振光显微镜获得了这些椎间盘的计算机断层扫描图像椎体终板。此外,该模型还用于预测基于人体腰椎间盘几何形状的轨迹,并将结果与之前报告的数据进行比较。最后,该模型还用于研究纤维角度分布中与椎间盘相关的潜在变化:结果:仅使用终板地形图和三个输入参数,该模型就能准确预测牛椎间盘和人椎间盘中经实验测量的纤维分布。重要的是,该模型再现了之前观察到的人类房颤后外侧左右手纤维倾斜度的不对称。据预测,人体腰椎间盘高度和纵横比的水平变化会影响纤维倾斜度的绝对值,但不会影响这种不对称:总之,这些结果表明,只需使用椎间盘几何形状和少量与受试者无关的参数,就可以将患者特定的腰椎间盘突出纤维方向分布轻松纳入脊柱计算模型中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Three-dimensional fiber patterning in the annulus fibrosus can be derived from vertebral endplate topography

Introduction

The annulus fibrosus (AF) of the Intervertebral disc (IVD) is composed of concentric lamellae of helically wound collagen fibers. Understanding the spatial variation of collagen fiber orientations in these lamellae, and the resulting material anisotropy, is crucial to predicting the mechanical behavior of the complete IVD.

Methods

This study builds on a prior model predicated on path-independent displacement of fiber endpoints during vertebral body growth to predict a complete, three-dimensional annulus fibrosus fiber network from a small number of subject-independent input parameters and vertebral endplate topographies obtained from clinical imaging. To evaluate the model, it was first fit to mid-plane fiber orientations obtained using polarized light microscopy in a population of bovine caudal discs for which computed tomography images vertebral endplates were also available. Additionally, the model was used to predict the trajectories based on human lumbar disc geometries and results were compared to previously reported data. Finally, the model was employed to investigate potential disc-related variations in fiber angle distributions.

Results

The model was able to accurately predict experimentally measured fiber distributions in both bovine and human discs using only endplate topography and three input parameters. Critically, the model recapitulated previously observed asymmetry between the inclinations of right- and left-handed fibers in the posterolateral aspect of the human AF. Level to level variation of disc height and aspect ratio in the human lumbar spine was predicted to affect absolute values of fiber inclination, but not this asymmetry.

Conclusion

Taken together these results suggest that patient-specific distributions of AF fiber orientation may be readily incorporated into computational models of the spine using only disc geometry and a small number of subject-independent parameters.

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来源期刊
JOR Spine
JOR Spine ORTHOPEDICS-
CiteScore
6.40
自引率
18.90%
发文量
42
审稿时长
10 weeks
期刊最新文献
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