YiYu Wang, M. S. S. Vinod Mouli, Min Ma, Fleur M. Ferguson
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引用次数: 0
摘要
最近的两项研究发现，(+)-JQ1（一种 BET 溴链的非降解抑制剂）的衍生物是一种分子胶，可通过瞬时靶标-连接酶相互作用的稳定机制招募 DCAF16 和 DCAF11。
Two recent studies identify derivatives of (+)-JQ1, a non-degrading inhibitor of BET bromodomains, as molecular glues that recruit DCAF16 and DCAF11 via mechanisms involving stabilization of transient target–ligase interactions.
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