菊粉:制药科学中的一种多元成分。

IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-07-29 DOI:10.1080/09205063.2024.2384276
Ruchi Tiwari, Pranshul Sethi, Shashi Ravi Suman Rudrangi, Pavan Kumar Padarthi, Vinod Kumar, Samatha Rudrangi, Krishna Vaghela
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引用次数: 0

摘要

菊粉是从菊苣根等植物中提取的天然多糖,因其具有多种治疗和功能特性,已成为医药科学中的重要成分。本综述探讨了菊粉的多方面应用,重点关注其化学结构、来源和作用机制。重点介绍菊粉作为益生元的作用,特别强调其调节肠道微生物群、增强肠道健康和改善代谢过程的能力。该综述还深入探讨了菊粉的治疗应用,包括其在控制糖尿病和脂质代谢等代谢健康问题方面的潜力,以及其免疫调节特性和对胃肠道健康的益处。此外,文章还探讨了在药物制剂和给药系统中加入菊粉的问题,讨论了菊粉作为稳定剂的用途及其对提高药物生物利用度的影响。文章探讨了以菊粉为基础的创新给药系统,如纳米颗粒和水凝胶在控释配方中的潜力。菊粉的功效得到了临床研究综述的支持,强调了它在控制糖尿病、心血管健康和胃肠道疾病等方面的益处。此外,还探讨了安全性、监管问题和潜在的副作用。最后,本综述深入探讨了菊粉在制药科学中应用的未来研究方向和相关挑战。
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Inulin: a multifaceted ingredient in pharmaceutical sciences.

Inulin, a naturally occurring polysaccharide derived from plants such as chicory root, has emerged as a significant ingredient in pharmaceutical sciences due to its diverse therapeutic and functional properties. This review explores the multifaceted applications of inulin, focusing on its chemical structure, sources, and mechanisms of action. Inulin's role as a prebiotic is highlighted, with particular emphasis on its ability to modulate gut microbiota, enhance gut health, and improve metabolic processes. The review also delves into the therapeutic applications of inulin, including its potential in managing metabolic health issues such as diabetes and lipid metabolism, as well as its immune-modulating properties and benefits in gastrointestinal health. Furthermore, the article examines the incorporation of inulin in drug formulation and delivery systems, discussing its use as a stabilizing agent and its impact on enhancing drug bioavailability. Innovative inulin-based delivery systems, such as nanoparticles and hydrogels, are explored for their potential in controlled release formulations. The efficacy of inulin is supported by a review of clinical studies, underscoring its benefits in managing conditions like diabetes, cardiovascular health, and gastrointestinal disorders. Safety profiles, regulatory aspects, and potential side effects are also addressed. This comprehensive review concludes with insights into future research directions and the challenges associated with the application of inulin in pharmaceutical sciences.

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来源期刊
Journal of Biomaterials Science, Polymer Edition
Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学:生物材料
CiteScore
7.10
自引率
5.60%
发文量
117
审稿时长
1.5 months
期刊介绍: The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.
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