肝脏移植:细胞生理、保存和损伤的考验。

IF 5.3 2区 医学 Q1 PHYSIOLOGY Physiology Pub Date : 2024-11-01 Epub Date: 2024-07-30 DOI:10.1152/physiol.00020.2024
B Martins, J Mossemann, F Aguilar, S Zhao, P J Bilan, B A Sayed
{"title":"肝脏移植:细胞生理、保存和损伤的考验。","authors":"B Martins, J Mossemann, F Aguilar, S Zhao, P J Bilan, B A Sayed","doi":"10.1152/physiol.00020.2024","DOIUrl":null,"url":null,"abstract":"<p><p>Liver transplantation has evolved into a mature clinical field, but scarcity of usable organs poses a unique challenge. Expanding the donor pool requires novel approaches for protecting hepatic physiology and cellular homeostasis. Here we define hepatocellular injury during transplantation, with an emphasis on modifiable cell death pathways as future therapeutics.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"401-411"},"PeriodicalIF":5.3000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Liver Transplantation: A Test of Cellular Physiology, Preservation, and Injury.\",\"authors\":\"B Martins, J Mossemann, F Aguilar, S Zhao, P J Bilan, B A Sayed\",\"doi\":\"10.1152/physiol.00020.2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Liver transplantation has evolved into a mature clinical field, but scarcity of usable organs poses a unique challenge. Expanding the donor pool requires novel approaches for protecting hepatic physiology and cellular homeostasis. Here we define hepatocellular injury during transplantation, with an emphasis on modifiable cell death pathways as future therapeutics.</p>\",\"PeriodicalId\":49694,\"journal\":{\"name\":\"Physiology\",\"volume\":\" \",\"pages\":\"401-411\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1152/physiol.00020.2024\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/physiol.00020.2024","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/30 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

肝移植已发展成为一个成熟的临床领域,但可用器官的稀缺性带来了独特的挑战。扩大供体库需要采用新的方法来保护肝脏生理和细胞稳态。在这里,我们定义了移植过程中的肝细胞损伤,重点是作为未来疗法的可改变的细胞死亡途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Liver Transplantation: A Test of Cellular Physiology, Preservation, and Injury.

Liver transplantation has evolved into a mature clinical field, but scarcity of usable organs poses a unique challenge. Expanding the donor pool requires novel approaches for protecting hepatic physiology and cellular homeostasis. Here we define hepatocellular injury during transplantation, with an emphasis on modifiable cell death pathways as future therapeutics.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Physiology
Physiology 医学-生理学
CiteScore
14.50
自引率
0.00%
发文量
37
期刊介绍: Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
期刊最新文献
Low-Grade Chronic Inflammation: a Shared Mechanism for Chronic Diseases. Mechanical Remodeling of Nuclear Biomolecular Condensates. Predictors of Inflammation-Mediated Preterm Birth. Factors Contributing to Heat Tolerance in Humans and Experimental Models. Harnessing Deep Learning Methods for Voltage-Gated Ion Channel Drug Discovery.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1