FGF1.

IF 2.2 3区生物学 Q4 CELL BIOLOGY Differentiation Pub Date : 2024-09-01 DOI:10.1016/j.diff.2024.100802

Sahar B. Jamal , Dorit Hockman

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引用次数: 0

摘要

成纤维细胞生长因子 1（Fgf1），又称酸性成纤维细胞生长因子（aFGF），参与调节从发育到疾病发病的各种生物过程。它是一种单链多肽，在成人大脑和肾脏组织中高度表达。研究表明，它的表达受多个组织特异性启动子的引导，这些启动子会产生不同长度的转录本。在发育过程中，Fgf1 基因广泛表达，包括在神经管、心脏和肺部。在标准实验室条件下，该基因的小鼠突变体是正常的。然而，据报道，当 Fgf1 突变体摄入高脂肪饮食时，会出现侵袭性糖尿病表型，同时脂肪组织异常扩张。对 FGF1 及其信号通路的持续研究有望加深对发育过程的理解，并开发出治疗糖尿病等疾病的新型干预方法。

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FGF1

Fibroblast Growth Factor 1 (Fgf1), also known as acidic FGF (aFGF), is involved in the regulation of various biological processes, ranging from development to disease pathogenesis. It is a single chain polypeptide and is highly expressed in adult brain and kidney tissues. Its expression has been shown to be directed by multiple tissue-specific promoters, which generate transcripts of varying lengths. During development the Fgf1 gene is widely expressed, including in the neural tube, heart and lung. Mouse mutants for this gene are normal under standard laboratory conditions. However, when Fgf1 mutants are exposed to a high fat diet, an aggressive diabetic phenotype has been reported, along with aberrant adipose tissue expansion. Ongoing research on FGF1 and its signalling pathways holds promise for greater understanding of developmental processes as well as the development of novel therapeutic interventions for diseases including diabetes.

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.