儿童获得性和遗传性缺锌相关疾病：病例系列和叙述性综述

IF 18 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-25 DOI:10.3390/pediatric16030051

Tommaso Bellini, M. Bustaffa, Barbara Tubino, Benedetta Giordano, Clelia Formigoni, Elena Fueri, Federica Casabona, Barbara Vanorio, Andrea Pastorino, Astrid Herzum, C. Matucci-Cerinic, S. Arrigo, G. Viglizzo, E. Piccotti

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引用次数: 0

摘要

锌缺乏是全球儿童健康的一个重大问题，表现为各种获得性和遗传性疾病。这篇关于儿童获得性和遗传性锌缺乏相关疾病的综述旨在探讨与这些疾病相关的临床表现、诊断难题和管理策略。本系列病例阐明了儿童患者缺锌的各种临床表现，包括皮炎、生长迟缓、免疫失调和神经系统异常等，并讨论了潜在的遗传机制、临床表型和治疗干预措施。儿童缺锌相关疾病的复杂性突出表明，需要儿科医生、皮肤科医生、遗传学家和营养学家共同参与的多学科方法来优化患者护理和治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acquired and Inherited Zinc Deficiency-Related Diseases in Children: A Case Series and a Narrative Review

Zinc deficiency is a significant global health concern among children, manifesting in various acquired and inherited conditions. This comprehensive overview of acquired and inherited zinc deficiency-related diseases in children aimed to explore the clinical presentations, diagnostic challenges, and management strategies associated with these conditions. This case series elucidates the diverse clinical manifestations of zinc deficiency in pediatric patients, ranging from dermatitis and growth retardation to immune dysregulation and neurological abnormalities, and discusses the underlying genetic mechanisms, clinical phenotypes, and therapeutic interventions. The complexity of zinc deficiency-related diseases in children underscores the need for a multidisciplinary approach involving pediatricians, dermatologists, geneticists, and nutritionists to optimize patient care and outcomes.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.