Formulation and In Vitro Evaluation of Dental Gel by Using Melaleuca alternifolia Oil

The study was aimed to develop and evaluate Dental Gel containing Melaleuca alternifolia oil as the chief constituent for the treatment of Dental Caries. It has a wide spectrum of antibacterial activity against a number of Dental Caries pathogens, hence it is selected for the treatment of Dental Caries. The gel is formulated by using carbopol 934 as gelling agent, Melaleuca alternifolia oil as medicinal agent, polyethylene glycol as co-solvent, methyl paraben as preservative, Glycerine as sweetening agent, and required quantity of distilled water as vehicle. The gel was evaluated for physical parameters like appearence, viscosity and it shown satisfactory results. The prepared gel was evaluated for various properties such as antimicrobial activity, pH, spreadability, extrudability, homogenecity, diffusion study, drug content etc. In-Vitro experiments demonstrated that the formulation F4 is an optimized and all results observed the pH 6.9, viscosity 45844, spreadability 3cm, homogenecity -Very Good, extrudability 95.2, drug content 97, diffusion Study 92.15, gel showed the zone of inhibition about 18 0.04mm. Key words: Melaleuca alternifolia oil, Carbopol 934, Diffusion Study, Zone of Inhibition.