癌症诊断前经常使用止痛药与情绪失调之间的关系

IF 2.4 Q1 NURSING Nursing Reports Pub Date : 2024-07-24 DOI:10.3390/nursrep14030136
Hyun Sook Oh, Subin Noh, Hwa Jeong Seo
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引用次数: 0

摘要

我们的目的是利用大规模队列数据库确定镇痛处方中镇痛药的使用与情绪障碍的发生和发展之间的关系。我们根据年龄、收入、健康相关变量、疾病史、Charlson 合并症指数和镇痛剂处方行为(模型 1-3),计算了患者罹患情绪障碍风险的危险比 (HR) 和 95% 置信区间 (CI)。此外,我们还使用比例危险回归模型确定了不同年龄组发生情绪障碍的风险(模型 4)。经年龄和收入调整后的 HR(模型 1)为 1.8275。经年龄、收入、体重指数和体力活动调整的 HR(模型 2)为 1.882。完全调整后的 HR(模型 3)为 1.698。与不使用镇痛药相比,非定期使用(HR = 1.386)和定期使用(HR = 1.698)与较高的情绪障碍风险相关。在 50 岁以上的患者中,参加体育锻炼(少于五天)的人比不参加体育锻炼的人患情绪障碍的风险低。这表明,体育锻炼可能有助于预防老年癌症幸存者的情绪障碍。合并症风险高和经常使用镇痛药是患情绪障碍的风险因素。因此,我们的研究结果表明,合并症风险高且有定期使用镇痛药史的癌症幸存者应接受仔细的心理咨询。
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Association between Regular Use of Analgesics before Cancer Diagnosis and Occurrence of Mood Disorders
We aimed to determine the relationship between the use of analgesics prescribed for pain management and the onset and progression of mood disorders using a large-scale cohort database. We calculated hazard ratios (HR) with 95% confidence intervals (CI) for patient risk of developing mood disorders based on age, income, health-related variables, disease history, Charlson comorbidity index, and analgesics prescription behavior (Models 1–3). Additionally, we determined the risk of mood disorder occurrence by age group (Model 4) using a proportional hazards regression model. The age- and income-adjusted HR (Model 1) was 1.8275. The age-, income-, BMI-, and physical-activity-adjusted HR (Model 2) was 1.882. The fully adjusted HR (Model 3) was 1.698. Compared with no analgesic use, nonregular use (HR = 1.386) and regular use (HR = 1.698) was associated with a higher risk of mood disorders. Among patients older than 50 years, those who participated in physical activity (less than five days) had a lower risk of mood disorders than those who did not. This suggests that it may be useful for preventing mood disorders in older cancer survivors. A high risk of comorbidities and regular use of analgesics are risk factors for developing mood disorders. Therefore, our results suggest that cancer survivors with a high risk of comorbidities and a history of regular analgesic use should undergo careful psychiatric consultation.
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来源期刊
Nursing Reports
Nursing Reports NURSING-
CiteScore
2.50
自引率
4.20%
发文量
78
期刊介绍: Nursing Reports is an open access, peer-reviewed, online-only journal that aims to influence the art and science of nursing by making rigorously conducted research accessible and understood to the full spectrum of practicing nurses, academics, educators and interested members of the public. The journal represents an exhilarating opportunity to make a unique and significant contribution to nursing and the wider community by addressing topics, theories and issues that concern the whole field of Nursing Science, including research, practice, policy and education. The primary intent of the journal is to present scientifically sound and influential empirical and theoretical studies, critical reviews and open debates to the global community of nurses. Short reports, opinions and insight into the plight of nurses the world-over will provide a voice for those of all cultures, governments and perspectives. The emphasis of Nursing Reports will be on ensuring that the highest quality of evidence and contribution is made available to the greatest number of nurses. Nursing Reports aims to make original, evidence-based, peer-reviewed research available to the global community of nurses and to interested members of the public. In addition, reviews of the literature, open debates on professional issues and short reports from around the world are invited to contribute to our vibrant and dynamic journal. All published work will adhere to the most stringent ethical standards and journalistic principles of fairness, worth and credibility. Our journal publishes Editorials, Original Articles, Review articles, Critical Debates, Short Reports from Around the Globe and Letters to the Editor.
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