领航生物力学领域:增强药物分析方法

Shanghui Sun
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摘要

在药物分析和检测中,化学发光是一种标准的技术方法,其原理是化学检测系统中被观测物质的浓度与化学发光强度在一定条件下建立线性定量关系。生物机械景观(BML)使用生物工程系统模拟人类肿瘤微环境的基本要素,已经在提高癌症生物学水平并帮助临床转化。大多数非法药物都会对心血管产生危险的副作用,从心律不齐到心脏病发作不等。注射非法麻醉品还可能导致心血管疾病,包括静脉堵塞以及动脉和心脏瓣膜的细菌感染。使用药物分析法检测此类心血管疾病的挑战性特征是心力衰竭、低血压和头痛。因此,在这项研究中,药物分析改进了针对心血管疾病的可穿戴人体传感器网络人工神经网络(WBSN-ANN)技术。WBSN-ANN 技术在医学和药物开发领域的应用,是因为它能在整个研究过程中提供临床背景下的患者状态信息以及有关药效学活性、有效性和安全性的重要信息。在这一过程中,研究密集型机构会发现一种新型化学或生物化合物,并将其开发成患者可以合法使用的药物,用于药物发现和开发。
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Navigating the biomechanical landscape: Enhanced methods for drug analysis
In drug analysis and detection, chemiluminescence is a standard technical method based on the idea that the concentration of observed substances in the chemical detection system and the chemical luminescence intensity establish a linear quantitative relationship under certain conditions. Bio-mechanical landscape (BML), which uses bioengineered systems to simulate essential elements of the human tumour microenvironment, is already enhancing cancer biology and aiding clinical translation. The majority of illicit substances have dangerous cardiovascular side effects that might range from an irregular heartbeat to a heart attack. Cardiovascular disease, including blocked veins and bacterial infections of the blood arteries and heart valves, may also result from injecting illicit narcotics. The challenging characteristics of such a cardiovascular disease using drug analysis are heart failure, low blood pressure and headaches. Hence, in this research, drug analysis has improved wearable body sensor network-enabled artificial neural network (WBSN-ANN) technologies for cardiovascular disease. Medicine and drug development because they provide information on patient status in the clinical context and vital information on pharmacodynamics activity, effectiveness, and safety throughout the research process. The process results in a research-intensive organization finding a novel chemical or biological compound and developing it into a medicine that patients can legally utilize for drug discovery and development.
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