抗糖尿病药物是治疗肥胖症的未来方向

Agnieszka Kuzio, Aleksandra Cieplińska, Kinga Ziojła-Lisowska
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摘要

肥胖症是一种发病机制复杂的多因素慢性疾病。其原因被认为是遗传、生物、表观遗传、环境、发育和行为因素导致热量摄入过多,进而导致体重增加。随着体重增加,罹患多种慢性疾病的风险也随之增加,预期寿命也因此缩短。肥胖症治疗的基础是改变行为和生活方式,主要是采用健康、均衡、热量不足的饮食,定期进行体育锻炼,限制久坐时间。如果效果不佳,则考虑采用药物治疗方法,必要时进行外科手术。如今,肥胖症作为一种必须得到有效治疗的多因素疾病,受到越来越多的关注。它不仅是一个美学问题,也是一种可导致过早死亡的严重疾病。我们的工作重点是回顾当前治疗肥胖症的方法,尤其关注最新的药物治疗方法。
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Antidiabetic drugs as the future of obesity treatment
Obesity is a multifactorial chronic disease with complex pathogenesis. Its causes are considered to be genetic, biological, epigenetic, environmental, developmental and behavioral factors leading to excessive caloric intake and, consequently, weight gain. As body weight increases, the risk of developing many chronic diseases increases and, as a result, life expectancy decreases. The basis of obesity treatment is the introduction of changes in behavior and lifestyle modification, based primarily on the adoption of a healthy, balanced diet with a caloric deficit, regular physical activity and limiting sedentary time. If they are ineffective, pharmacological methods are considered and, if necessary, surgical procedures are performed. Nowadays, more and more attention is paid to obesity as a multifactorial disease that must be effectively treated. It is not only an aesthetic problem but also a serious disease that can lead to premature death. Our work focuses on a review of current methods in the treatment of obesity, with particular attention to the latest pharmacological methods.
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