大麻素治疗帕金森病的现有方案

Piotr Zdziebło, Ewelina Machała-Ćwikła, Urszula Łapińska, Piotr Ćwikła, Kamila Machała, Anna Zdziebło, Dominika Machała, Katarzyna Zdziebło, Anna Bieniasz
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摘要

大麻素作为治疗疾病的药剂的效用是时下流行的讨论话题。医用大麻的批准继续引发争议。早在古代,大麻就被用于药用目的。这些植物能够产生植物化学物质和其他化合物,如类黄酮和萜烯。不同种类的大麻在特定化合物的含量上有所不同,因此可能具有不同的用途。大麻中最著名的植物大麻素是δ-9-四氢大麻酚(THC)和大麻二酚(CBD)。它们具有部分相反的作用,并与人体组织中内源性大麻素系统的相应受体相互作用。我们还将大麻素分为内源性大麻素(EC)和合成大麻素(SC)。THC 和 CBD 对人体的影响仍在研究之中。媒体上出现的关于它们的信息往往报道不准确或不完整。目前,关于使用大麻素治疗和缓解多种疾病症状的研究越来越多。由于 THC 和 CBD 具有神经保护作用,研究人员的工作重点是用它们来治疗神经退行性疾病,其中包括帕金森病(PD)。
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Current options for cannabinoids in the treatment of Parkinson's disease
The utility of cannabinoids as agents used to treat diseases is a popular topic of discussion these days. The approval of medical marijuana continues to stir up controversy. As far back as ancient times, hemp was used for medicinal purposes. These plants have the ability to produce phytochemicals and other compounds such as flavonoids and terpenes. Respective species of hemp differ in the content of particular chemical compounds and therefore have different possible uses. Among the best-known phytocannabinoids found in hemp are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). They have partially opposing effects and interact with the corresponding receptors of the endocannabinoid system in the body's tissues. We also distinguish between cannabinoids of endogenous origin - endocannabinoids (EC) and synthetic cannabinoids (SC). The effects of THC and CBD on the human body are still being studied. Information about them that appears in the media, is often reported inaccurately or incompletely. There is now a growing body of research into the use of cannabinoids to treat and alleviate the symptoms of many diseases. Due to the neuroprotective effects of THC and CBD, researchers' work has focused on using them to treat neurodegenerative diseases, which include Parkinson's disease (PD).
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