代谢综合征和甲状腺疾病导致心血管疾病的风险

Ravi Shankar, Neha Sharma, Ajay Kumar, Raju Ram, Aparajita Kushwaha
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摘要

目的:代谢综合征(MetS)是最广泛使用的术语,指代谢异常的集合体,会导致心血管病变风险的增加。代谢综合征的发病率在全球范围内不断上升,有明显证据表明其在印度和其他南亚国家的发病率很高。甲状腺功能障碍,主要是亚临床甲状腺功能减退症,在 MetS 患者中的发病率高于普通人群:这项横断面观察性研究在乌代布尔太平洋医学科学研究所的普通人群和近亲属(350 人)中的 MetS 患者中进行。胃肽酶(胃泌素和肥胖素)和胰岛素的测定采用酶联免疫吸附法。甲状腺激素通过化学发光法测定:本分析的主要发现是胰岛素和胃泌素之间存在显著的负相关。在没有心血管疾病(CVD)的个体中也观察到了这种负相关关系,这表明即使没有明显的心血管疾病,胰岛素也可能在调节胃泌素水平方面发挥作用。鉴于胃泌素在食欲调节和能量平衡中的作用,这一发现尤其值得注意:研究结果强调,在进行健康评估和管理时需要采取综合方法,考虑年龄、性别、是否存在潜在的健康问题以及甲状腺疾病等个体因素。
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METABOLIC SYNDROME AND RISK OF CARDIOVASCULAR DISEASE WITH THYROID DISORDER
Objectives: Metabolic syndrome (MetS) is the most widely used term for the aggregation of metabolic abnormalities, which leads to an increase in the risk of developing cardiovascular pathology. The prevalence of MetS is increasing all over the world with distinct evidence of high prevalence in India and other South Asian countries. Thyroid dysfunction, prominently subclinical hypothyroidism, has been observed more frequently in patients of MetS than in the general population. Methods: This cross-sectional, observational study was conducted among MetS patients in the general population and near and dear of patients (350) at the Pacific Institute of Medical Sciences, Udaipur. For the determination of gastric peptidases (ghrelin and obestatin), insulin was done by enzyme-linked immunosorbent assay. Thyroid hormones are determined by chemiluminescence. Results: The key findings in this analysis are the significant negative correlation between insulin and ghrelin. This inverse relationship was observed in individuals without cardiovascular disease (CVD), suggesting that even in the absence of overt CVD, insulin may play a role in regulating ghrelin levels. This finding is particularly noteworthy given ghrelin’s role in appetite regulation and energy balance. Conclusion: The findings emphasize the need for a holistic approach to health assessment and management, considering individual factors such as age, sex, and the presence of underlying health conditions along with thyroid disorders.
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