一名高危 MDS 老年患者的微移植：病例报告和文献综述

IF 0.7 Q4 HEMATOLOGY Leukemia Research Reports Pub Date : 2024-01-01 DOI:10.1016/j.lrr.2024.100475

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引用次数: 0

摘要

导言骨髓增生异常综合征（MDS）（极高危）患者的预后很差。HLA 不匹配的异体 T 细胞输注（即微移植）不仅能缩短骨髓抑制时间，还能改善患者的治疗反应。病例介绍一位 74 岁的女性患者因乏力前来就诊，血常规检查显示为全血细胞减少。经过骨髓检查，她被确诊为 MDS（极高危），随后接受了 4 个周期的微移植。讨论该患者对微量移植的耐受性良好，毒性反应可控，骨髓抑制时间短。

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Micro-transplantation in an elderly patient with very high risk MDS:A case report and literature review

Introduction

The prognosis of patients with myelodysplastic syndromes (MDS) (very high risk) is poor.HLA-mismatched allogeneic T-cell infusion which is called micro-transplantation can not only shorten the time of bone marrow suppression, but also improve the treatment response of patients.

Case presentation

A 74-year-old woman presented with fatigue and showed pancytopenia on routine blood count. She was diagnosed with MDS (very high risk) after bone marrow examination,then she received 4 cycles of micro-transplantation. The progression-free survival was 22 months and overall survival was 33 months.