牛基因组学最新技术发展综述

IF 1.9 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Veterinary and Animal Science Pub Date : 2024-07-23 DOI:10.1016/j.vas.2024.100382
Navid Ghavi Hossein-Zadeh
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引用次数: 0

摘要

牛因其牛奶、牛肉、粪便、皮毛和起草能力而被视为非常珍贵的动物。科学界尝试了多种策略来改良牛种质的基因构成。为了确保奶牛业和牛肉业获得更高的回报,研究人员面临的最大挑战是改良具有重要商业价值的性状。在过去几十年中,牛基因改良工具的最大发展之一就是基因组的发现。中密度和高密度单核苷酸多态性(SNP)阵列的出现以及先进的统计技术使基因组选择成为可能,从而给家畜育种带来了革命性的变化。获取牛的高维基因组数据变得越来越容易。基因分型成本的持续下降和利用基因组数据提高投资回报率的服务的增加都为此做出了重要贡献。基因组学领域取得了长足的进步,这要归功于一些突破性发现,如辐射杂交制图、原位杂交、同源染色体分析、体细胞遗传学、细胞遗传图谱、分子标记、数量性状位点关联研究、高通量 SNP 基因分型、从全基因组枪式测序到全基因组制图以及基因组编辑。这些进展对牛基因组学领域产生了重大的积极影响。本稿件旨在回顾牛育种基因组学技术的最新进展以及该领域的未来前景。
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An overview of recent technological developments in bovine genomics

Cattle are regarded as highly valuable animals because of their milk, beef, dung, fur, and ability to draft. The scientific community has tried a number of strategies to improve the genetic makeup of bovine germplasm. To ensure higher returns for the dairy and beef industries, researchers face their greatest challenge in improving commercially important traits. One of the biggest developments in the last few decades in the creation of instruments for cattle genetic improvement is the discovery of the genome. Breeding livestock is being revolutionized by genomic selection made possible by the availability of medium- and high-density single nucleotide polymorphism (SNP) arrays coupled with sophisticated statistical techniques. It is becoming easier to access high-dimensional genomic data in cattle. Continuously declining genotyping costs and an increase in services that use genomic data to increase return on investment have both made a significant contribution to this. The field of genomics has come a long way thanks to groundbreaking discoveries such as radiation-hybrid mapping, in situ hybridization, synteny analysis, somatic cell genetics, cytogenetic maps, molecular markers, association studies for quantitative trait loci, high-throughput SNP genotyping, whole-genome shotgun sequencing to whole-genome mapping, and genome editing. These advancements have had a significant positive impact on the field of cattle genomics. This manuscript aimed to review recent advances in genomic technologies for cattle breeding and future prospects in this field.

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来源期刊
Veterinary and Animal Science
Veterinary and Animal Science Veterinary-Veterinary (all)
CiteScore
3.50
自引率
0.00%
发文量
43
审稿时长
47 days
期刊最新文献
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