抗菌光动力疗法对疼痛和口腔健康相关生活质量的影响:文献综述

IF 3.4 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Dental Sciences Pub Date : 2024-07-17 DOI:10.1016/j.jds.2024.06.022
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引用次数: 0

摘要

抗菌光动力疗法(aPDT)是一种用于微生物净化的非侵入性方法,也可作为治疗口腔感染的辅助策略。越来越多的人认识到,长期治疗的成功与否受患者对疾病及其改善的看法的影响。最近,有人建议将 aPDT 作为组织修复、减轻疼痛和提高口腔健康相关生活质量(OHRQoL)的双重方法。第一种途径涉及 aPDT 的抗菌和消炎作用。它不仅能消除微生物,还有助于调节免疫反应和减少炎症,从而使愈合过程更快、更有效。这反过来又能缓解疼痛和相关症状,有助于控制治疗并发症。第二个途径涉及 aPDT 调节痛觉和减轻疼痛的能力。aPDT 通过释放神经递质(如 β-内啡肽、5-羟色胺和乙酰胆碱酯酶)诱导镇痛。它还能通过光感受器与线粒体相互作用,启动细胞内过程,从而减轻疼痛。此外,该疗法还能抑制神经纤维,减少神经冲动传导,改变疼痛阈值。考虑到对患者疼痛和 OHRQoL 的影响是决策过程的一个重要方面,本研究旨在回顾 aPDT 期间基于患者的结果测量,并评估其对患者疼痛和 OHRQoL 的影响。了解这些因素将有助于更好地评估无创口腔黏膜剥脱术作为口腔感染治疗方案的总体益处和有效性。
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The impact of antimicrobial photodynamic therapy on pain and oral health-related quality of life: A literature review

Antimicrobial photodynamic therapy (aPDT) is a non-invasive approach used for microbial decontamination, and it can also be beneficial as an adjunctive strategy for oral infections. The success of treatment in the long term is increasingly recognized to be influenced by patient's perception of the disease and its improvement. Recently, aPDT has been suggested as a dual approach to tissue repair, pain relief, and enhancement of oral health-related quality of life (OHRQoL). The first pathway involves the antimicrobial and anti-inflammatory effects of aPDT. It not only eliminates microorganisms but also helps regulate the immune response and reduce inflammation, leading to a faster and more effective healing process. This, in turn, provides relief from pain and associated symptoms, aiding in the management of treatment complications. The second pathway involves aPDT's ability to modulate nociception and alleviate pain. aPDT induces analgesia by releasing neurotransmitters such as β-endorphin, serotonin, and acetylcholinesterase. It also interacts with mitochondria through photoreceptors, initiating intracellular processes that alleviate pain. Furthermore, the therapy inhibits nerve fibers, reducing nerve impulse conduction and altering the pain threshold. Considering that the impact on patients' pain and OHRQoL is an important aspect of the decision-making process, this study aimed to review patient-based outcome measures during aPDT and assess its effects on pain and OHRQoL in patients. Understanding these factors will contribute to a better assessment of the overall benefits and effectiveness of aPDT as a treatment option for oral infections.

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来源期刊
Journal of Dental Sciences
Journal of Dental Sciences 医学-牙科与口腔外科
CiteScore
5.10
自引率
14.30%
发文量
348
审稿时长
6 days
期刊介绍: he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.
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