The use of ubiquinone to improve the healing of soft and hard jaw tissues – A systematic review

Objective

The aim of the present study was to survey the scientific literature for conclusive evidence about the capacity of ubiquinone to improve the healing process of soft and hard jaw tissue.

Methods

A systematic review was conducted according to the PRISMA 2020 statement. An electronic search was undertaken in six databases and in the gray literature.

Results

Eight studies were identified, four of them in vitro, three in vivo, and one clinical. All articles demonstrated that ubiquinone accelerates the repair of soft tissue, whereas one study found little effect on the remodeling of bone tissue. Despite the possibility that ubiquinone application may be beneficial, the limited knowledge about the action of this coenzyme on oral tissue repair requires further preclinical studies before the development of human clinical trials.

Conclusion

This systematic review provides valuable information about potential new medications that could help the healing of oral tissues, especially for oral and maxillofacial surgeons.