产妇感染 SARS-CoV-2 与新生儿易感性的关系：回顾性队列研究

IF 2.7 Q3 IMMUNOLOGY Vaccine: X Pub Date : 2024-07-26 DOI:10.1016/j.jvacx.2024.100536

Xiao-Dan Zhu , Yan-Jie Peng , Ying Chen , Mei Xue , Ai-Juan Zhang , Yu Peng , Rong Mei , Mei-Rong Tian , Lin Zhang

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引用次数: 0

摘要

方法我们进行了一项回顾性队列研究，将 1089 名孕龄≥28 周的孕妇分为感染组和未感染组。通过全面查阅电子病历和电话随访收集了所有参与者的数据。结果发现，产妇接种疫苗（OR 95%CI：0.63[0.46, 0.85]）和产妇感染 SARS-CoV-2（OR 95%CI：0.45[0.34, 0.60]）与新生儿感染风险的降低有关。与未感染组（45.15%）相比，感染组的新生儿 SARS-CoV-2 感染率（25.93%）较低。逻辑回归分析确定了与新生儿感染风险增加相关的几个风险因素，包括妊娠体重指数（OR 95%CI：1.04[1.01, 1.08]）、首次妊娠年龄（OR 95%CI：1.05[1.01, 1.10]）、经产妇年龄（OR 95%CI：1.05[1.01, 1.08]）、新生儿感染风险（OR 95%CI：1.04[1.01, 1.08]）。结论母亲接种 SARS-CoV-2 疫苗和围产期感染 SARS-CoV-2 对预防新生儿 SARS-CoV-2 感染具有保护作用。

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Association of maternal infection of SARS-CoV-2 and neonatal susceptibility: A retrospective cohort study

Objective

This study aims to assess the risk of neonatal susceptibility to COVID-19 among pregnant women.

Methods

We conducted a retrospective cohort study involving 1089 pregnant women ≥28 weeks of gestational age, who were categorized into infected and uninfected groups. Data for all participants were collected through a comprehensive review of electronic medical records and follow-up phone calls. The primary outcome was neonatal infection with SARS-CoV-2, while secondary outcomes included delivery patterns and gestational age at delivery.

Results

Maternal vaccination (OR 95%CI:0.63[0.46, 0.85]) and maternal infection with SARS-CoV-2 (OR 95%CI: 0.45[0.34, 0.60]) were found to be associated with a decreased risk of neonatal infection. The infected group exhibited a lower neonatal SARS-CoV-2 infection rate (25.93%) compared to the uninfected group (45.15%). Logistic regression analysis identified several risk factors associated with an increased risk of neonatal infection, including pregnancy BMI (OR 95%CI: 1.04[1.01, 1.08]), age at first pregnancy (OR 95%CI: 1.05[1.01, 1.10]), age at menarche (OR 95%CI: 1.13[1.02, 1.26]), and parturition (Yes vs. No) (OR 95%CI:1.4 [1.04,1.88]).