Vaccine: X最新文献

{"title":"A qualitative exploration of stakeholders' views on vaccines for the elderly in South Africa","authors":"Mncengeli Sibanda ,&nbsp;Rosemary J. Burnett ,&nbsp;Brian Godman ,&nbsp;Edina Amponsah-Dacosta ,&nbsp;Johanna C. Meyer","doi":"10.1016/j.jvacx.2026.100779","DOIUrl":"10.1016/j.jvacx.2026.100779","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Advancements in healthcare and living standards have led to increased life expectancy globally, including in South Africa. Despite considerable evidence from high-income countries that vaccination is a cost-effective strategy for healthy ageing, South Africa currently does not have a formal policy for vaccination of the elderly. This study explored the opinions, experiences and recommendations of South African stakeholders (experts and key opinion leaders) in the field of vaccines and healthy ageing.</div></div><div><h3>Methodology</h3><div>Online qualitative in-depth interviews with 16 stakeholders (vaccinologists, infectious disease specialists, policymakers, geriatricians and epidemiologists) were conducted. Interviews were recorded, transcribed, coded and analysed thematically using NVivo 12.0™ software.</div></div><div><h3>Results</h3><div>The overarching unanimous theme was that a national immunisation programme for the elderly (NIPE) is warranted. Aligned to this were the themes: (i) Immunisation schedule for the elderly; (ii) Health system NIPE readiness; and (iii) Strategies ensuring adequate vaccine uptake by the elderly. Participants recommended a coordinated NIPE, which could build on the successes of the Expanded Programme on Immunisation of South Africa (EPI-SA) and the recent COVID-19 vaccination programme. The NIPE should ideally be integrated into the existing primary healthcare (PHC) system programmes for the elderly. Concurrently, interventions to increase access to vaccines and reduce vaccine hesitancy among the elderly and their healthcare providers must be implemented.</div></div><div><h3>Conclusion</h3><div>A NIPE needs to be prioritised, understood, communicated, and implemented within EPI-SA and integrated into the PHC system. This should be accompanied by the requisite logistical and financial support for such a programme. The NIPE should build on the success and achievements of EPI-SA and the COVID-19 vaccination programme. Interventions that increase vaccine access and address vaccine hesitancy should also be implemented to enhance uptake by the elderly.</div></div>","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100779"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic factors of knowledge, conspiracy beliefs, and attitudes toward Mpox among healthcare workers in Sierra Leone","authors":"Augustus Osborne ,&nbsp;Alhaji Mustapha Abu ,&nbsp;Ahmed Vandy","doi":"10.1016/j.jvacx.2026.100799","DOIUrl":"10.1016/j.jvacx.2026.100799","url":null,"abstract":"<div><h3>Background</h3><div>Mpox, a re-emerging zoonotic disease, poses a global health threat. In Sierra Leone, healthcare workers (HCWs) are central to outbreak response, yet little is known about their knowledge, conspiracy beliefs, and attitudes. This study assessed these factors and identified associated sociodemographic characteristics.</div></div><div><h3>Methods</h3><div>This cross-sectional study recruited 318 HCWs from three hospitals in Freetown using stratified random sampling. Eligible participants had at least one year of professional experience; those on leave or unwilling to participate were excluded. Data was collected using a researcher-developed questionnaire. Multivariable logistic regression identified factors, while correlation and linear regression examined interrelationships, with significance set at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>The mean knowledge score was 65.8% (±23.7), with 53.8% showing good knowledge. Urban residence (AOR: 5.70, 95% CI: 3.01–10.80) and older age (AOR: 8.92, 95% CI: 1.76–45.15) predicted better knowledge, while clinical staff scored lower (AOR: 0.06, 95% CI: 0.02–0.15). Conspiracy beliefs were high in 44.7% of HCWs, with females more susceptible (AOR: 2.41, 95% CI: 1.31–4.43), while higher education was protective (AOR: 0.32, 95% CI: 0.16–0.63). Attitudes were polarized (49.7% positive, 50.3% negative), with good knowledge (AOR: 3.90, 95% CI: 2.01–7.54) and urban residence (AOR: 2.13, 95% CI: 1.24–3.67) predicting positive attitudes. Knowledge and attitudes were positively correlated (<em>r</em> = 0.323, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Moderate knowledge, widespread conspiracy beliefs, and divided attitudes among HCWs underscore the need for targeted training and communication strategies. Addressing misinformation and strengthening knowledge, particularly among rural and clinical staff, are essential for Mpox preparedness in resource-limited settings.</div></div>","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100799"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147420334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying factors associated with acceptance of the fourth COVID-19 vaccine dose: A multicentre cross-sectional study in Indonesia","authors":"Muh. Akbar Bahar ,&nbsp;Abd. Rafik Mohi ,&nbsp;Ikhwan Yuda Kusuma ,&nbsp;Dezső Csupor ,&nbsp;Muh. Nasrum Massi","doi":"10.1016/j.jvacx.2026.100784","DOIUrl":"10.1016/j.jvacx.2026.100784","url":null,"abstract":"<div><h3>Background</h3><div>Although the World Health Organization declared the end of COVID-19 as a global health emergency in May 2023, COVID-19 remains a public health concern due to continued transmission, variants, and waning immunity. However, the number of individuals who have received a complete series of COVID-19 vaccinations in developing countries, such as Indonesia, is still limited.</div></div><div><h3>Objective</h3><div>This study aimed to explore the factors influencing the acceptance of the fourth dose of the COVID-19 vaccine in Indonesia.</div></div><div><h3>Methods</h3><div>A multicentre cross-sectional study using an online questionnaire was conducted from June to September 2023 among the Indonesian population aged 18 years and older. The validated self-administered questionnaire consists of three parts: sociodemographic variables, clinical history, and domains of the Health Belief Model (perceived severity, perceived susceptibility, perceived clinical barriers, perceived barriers to access to booster vaccination and perceived benefits of booster vaccine). Multivariate logistic regression was employed to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for independent variables associated with acceptance of the fourth dose of the COVID-19 vaccine.</div></div><div><h3>Results</h3><div>Of 1850 eligible participants, only 11% had received the fourth dose of the COVID-19 vaccine. The independent determinants of the acceptance of the fourth dose of the COVID-19 vaccine were as follows: age groups 26–35 years (OR: 1.73, 95%CI: 1.00–3.01), 36–45 years (OR: 2.65, 95%CI: 1.35–5.21), and over 45 years (OR: 3.68, 95%CI: 2.05–6.63); working as a healthcare worker (OR: 2.03, 95%CI: 1.11–3.69); having a chronic disease (OR: 1.71, 95%CI: 1.07–2.73); history of COVID-19 infection (OR: 1.64, 95%CI: 1.12–2.41); perceived susceptibility to COVID-19 (OR: 1.31, 95%CI: 1.09–1.57); and perceived benefits of the booster vaccine (OR: 1.27, 95%CI: 1.04–1.56).</div></div><div><h3>Conclusion</h3><div>The acceptance of the fourth COVID-19 vaccine booster in Indonesia remained low, despite substantial evidence demonstrating its effectiveness and safety, particularly in protecting vulnerable populations. Vaccine coverage could be improved by campaigns based on key determinants of acceptance such as age, chronic disease, COVID-19 infection history and perceptions of vulnerability to infection and benefits of the vaccine.</div></div>","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100784"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of religious affiliation and political news on parental vaccination intent during COVID-19 pandemic","authors":"Jake Stevens,&nbsp;Kallysta Strong,&nbsp;Ella Madsen,&nbsp;Jeffrey Glenn,&nbsp;Erik J. Nelson","doi":"10.1016/j.jvacx.2026.100781","DOIUrl":"10.1016/j.jvacx.2026.100781","url":null,"abstract":"<div><h3>Background</h3><div>In May 2021, COVID-19 vaccines became available for adolescents aged 12–15. However, safety concerns, misinformation, and politicization surrounding the vaccine left some parents hesitant to vaccinate their children. This study analyzes how media sources and religious affiliation were associated with parental COVID-19 vaccination intent.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis of 5552 parents in the May 2021 COVID-19 Rapid Research Response Survey of the Adolescent Brain Cognitive Development (ABCD) study, which collected data on parental intention to vaccinate their children against COVID-19 just before the FDA approved the first vaccine for children aged 12–15. Parental vaccination intent was analyzed by media sources, religious affiliation, and other sociodemographic factors. We also fit a log-binomial regression model to examine the impact of media sources and religious affiliation on parental vaccination intent, controlling for sociodemographic factors.</div></div><div><h3>Results</h3><div>We found that, compared to parents consuming balanced media sources, parents consuming right-leaning media sources were less likely to plan to vaccinate their children [PR = 0.53 (0.47, 0.6)], while parents consuming left-leaning media sources were not significantly different from parents consuming balanced media [PR = 1.06 (0.99, 1.12)]. We also found differences in vaccination intent by religious affiliation. Compared to Christian parents, Agnostic/Atheist parents were more likely to plan to vaccinate their children [PR = 1.41 (1.35, 1.47)], as were Jewish parents [PR = 1.32 (1.22, 1.43)], and parents with no religious affiliation [(PR = 1.18 (1.14, 1.23)].</div></div><div><h3>Conclusions</h3><div>Our study highlights the multifaceted factors influencing vaccine hesitancy among parents of adolescents during the COVID-19 pandemic. To create effective public health strategies for future outbreaks, it is crucial to better understand the complex interplay of religious affiliation and media bias with vaccine hesitancy.</div></div>","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100781"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding divergent parental decisions: Declining pertussis vaccination during pregnancy while accepting infant immunisation - A qualitative study.","authors":"Daniël C.M. Huijten ,&nbsp;Saskia den Ambtman ,&nbsp;Liesse M.L. Vanderhoven ,&nbsp;Veja Widdershoven ,&nbsp;Christian J.P.A. Hoebe ,&nbsp;Rianne P. Reijs","doi":"10.1016/j.jvacx.2026.100800","DOIUrl":"10.1016/j.jvacx.2026.100800","url":null,"abstract":"<div><h3>Background</h3><div>Pertussis vaccination during pregnancy (VdP) is around 90% effective in protecting infants against pertussis. Passive immunisation protects infants until they are old enough to receive active immunisation themselves. Over a quarter of Dutch infants participating in the National Immunisation Program have mothers who did not receive pertussis VdP. This study aimed to identify factors related to vaccination care that influenced mothers' decision not to receive the pertussis VdP, while accepting a pertussis vaccination for their infants.</div></div><div><h3>Methods</h3><div>Semi-structured in-depth interviews were conducted with Dutch mothers, within six months postpartum, across four regions in the Netherlands: The Hague, Utrecht, and southern parts of the Dutch provinces Gelderland and Limburg. Interviews were analysed with the use of the Thematic Codebook Analysis method.</div></div><div><h3>Results</h3><div>A total of 22 participants were interviewed. The participants were diverse in age (range: 23–41) and thirteen were of Western-European origin. All participants indicated that there was not one specific reason for rejecting pertussis VdP yet accepting infant vaccination against pertussis. Their decision-making process was complex, influenced by prior experiences and pre-established views, outcome expectations, information service, trust in vaccinations and professionals, decision-making abilities, and organisational determinants.</div></div><div><h3>Conclusion</h3><div>Both decisions to decline the pertussis VdP and to accept infant pertussis vaccination take place within a dynamic societal context. Open conversations between pregnant women and healthcare professionals about VdP and infant vaccinations are essential to support informed decision-making. Understanding this process can help healthcare organisations tailor and personalise vaccination services, moving away from standardised procedures.</div></div>","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100800"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The projected cost-effectiveness and budget impact of alternative HPV vaccines in Senegal: A modeling study","authors":"Oumaima Laraj ,&nbsp;Maryam Diarra ,&nbsp;Cheikh Talla ,&nbsp;Rokhaya Diop ,&nbsp;Ousseynou Badiane ,&nbsp;Karell Pelle ,&nbsp;Amira Kebir ,&nbsp;Slimane BenMiled ,&nbsp;Cheikh Loucoubar","doi":"10.1016/j.jvacx.2026.100792","DOIUrl":"10.1016/j.jvacx.2026.100792","url":null,"abstract":"<div><h3>Background:</h3><div>Cervical cancer remains a leading cause of morbidity and mortality among women in Senegal. In 2018, with support from Gavi, Senegal introduced HPV vaccination into its immunization program using a two-dose Gardasil-4 schedule for 9-year-old girls. As Senegal approaches transition from Gavi support, full vaccine procurement costs will shift to the government, necessitating evidence-based decisions on the most cost-effective vaccination strategies. This study evaluates the health and economic value of alternative HPV vaccination options to inform sustainable and equitable policy.</div></div><div><h3>Methods:</h3><div>A static cohort model assessed the cost-effectiveness and budget impact of 23 HPV vaccination strategies varying by vaccine type (Gardasil-4, Gardasil-9, Cervarix, Cecolin), dose number (one versus two), and coverage level (current, 70%, WHO target). Health and cost outcomes were simulated for 9-year-old girls vaccinated annually from 2019 to 2034. Outcomes included cervical cancer cases, deaths, and DALYs averted. Costs were evaluated from a government perspective in 2022 USD, applying a 3% discount rate. Input parameters were from GLOBOCAN 2020, literature, and national data. Sensitivity analyses explored uncertainty around key assumptions.</div></div><div><h3>Results:</h3><div>All HPV vaccination strategies were cost-effective under a willingness-to-pay threshold of 30% of GDP per capita (USD 450 per DALY averted). Cecolin-based strategies, particularly one-dose schedules with expanded coverage, yielded the most favorable cost-effectiveness ratios. Gardasil-9 offered the greatest health benefits (up to 112,866 DALYs averted) but required higher programmatic investments, limiting cost-effectiveness unless prices decreased. Five strategies, mainly Cecolin and one-dose Gardasil-9, were efficient under national thresholds. At lower thresholds, such as 7% of GDP per capita (USD 100), one-dose Cecolin with 90% coverage was optimal.</div></div><div><h3>Conclusion:</h3><div>HPV vaccination in Senegal is highly cost-effective. Cecolin one-dose strategies offer a scalable, affordable approach post-Gavi transition, while Gardasil-9 is viable only with price reductions. Aligning vaccine choice with cost-effectiveness and feasibility is essential for long-term sustainability and equitable health outcomes.</div></div>","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100792"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation of electrospinning and electrospraying for the development of novel live virus vaccine formulations","authors":"Edit Hirsch ,&nbsp;Bettina Fazekas ,&nbsp;Orsolya Péterfi ,&nbsp;Lajos Madarász ,&nbsp;György Marosi ,&nbsp;Csenge Hanna Tolnai ,&nbsp;Petra Forgách ,&nbsp;András Marosi","doi":"10.1016/j.jvacx.2026.100793","DOIUrl":"10.1016/j.jvacx.2026.100793","url":null,"abstract":"<div><div>Despite a growing interest in alternative vaccination routes, there are challenges in formulation that limit efficiency of oral or pulmonary vaccines, especially in livestock animals. Electrospinning (ES) and electrospraying offer gentle drying at room temperature, making them suitable for the formulation of biopharmaceuticals, including live virus particles. In this study, first a polyvinyl pirrolydone (PVPVA64)-based matrix system was developed and evaluated for product morphology and downstream processability to adapt the technology for virus carriage. The optimal concentration of the aqueous polymer solution was 45% for oral administration (resulting in nanofibers), and 30% for aerogenic delivery (producing nanoparticles). An automated AI tool, based on machine vision, was established for the control of particle size distribution. The study continued with the integration of three different (enveloped and non-enveloped) viruses into electrospun nanofibers, using a high-speed ES setup. PVPVA64 and polyvinyl alcohol with polyethylene oxide (PVA-PEO) were chosen as biocompatible matrix polymers, supplemented with mannitol or sucrose excipients. After optimization of the environmental conditions, changes of viral infectious titers upon production and storage were analyzed, comparing the different polymer-stabilizer combinations used. While notable variance was detected between the results of different viruses, sucrose was overall more effective in the protection of viral infectivity at the initial stage (the ES process), while mannitol had a superior protective effect during later storage. PVPVA64 supplemented with mannitol was the best combination regarding all-round stability of virus-loaded nanofibers. Using the same matrix (PVPVA64-mannitol), electrosprayed nanoparticles were also constructed to encapsulate the porcine coronavirus TGEV, where viral titers showed even higher long-term stability than in nanofibers. Our results prove the high potential of ES and electrospraying for the dry formulation of viruses. With further research, these technologies might open up new possibilities in vaccination against viral diseases of animals and humans.</div></div>","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100793"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparturient sow vaccination with a rIdeSsuis derivative: Immunogenicity and protective efficacy against Streptococcus suis serotype 14","authors":"Carolin Liedel ,&nbsp;Leonie Mayer ,&nbsp;Christine Weiße ,&nbsp;Haukur L. Sigmarsson ,&nbsp;Iris Völker ,&nbsp;Christoph G. Baums ,&nbsp;Karoline Rieckmann","doi":"10.1016/j.jvacx.2026.100794","DOIUrl":"10.1016/j.jvacx.2026.100794","url":null,"abstract":"<div><div><em>Streptococcus (S.) suis</em> is an important causative agent of arthritis, meningitis and septicemia affecting pigs of different age groups, including suckling piglets. Accordingly, early protection of piglets against this pathogen is highly relevant. Vaccination of piglets with the recombinant IgM degrading enzyme of <em>S. suis</em>, Ide_{<em>Ssuis</em>}, confers protection against mortality in weaning piglets experimentally challenged with serotypes (<em>cps</em>) 2 and 14 of sequence type 1 or 9 of sequence types 50 and 94. The aim of this study was to determine immunogenicity and protective efficacy in the offspring of sows prime-boost vaccinated with a recombinant variant of Ide_{<em>Ssuis</em>} formulated with the adjuvant Montanide ISA 25. Sows were vaccinated 5 and 2 weeks prior to farrowing and developed high levels of serum and colostrum α-Ide_{<em>Ssuis</em>} IgG antibodies, which were shown to neutralize the IgM cleaving activity of Ide_{<em>Ssuis</em>}. Piglets suckled by immunized sows had significantly higher specific α-Ide_{<em>Ssuis</em>} IgG antibody levels compared to control piglets until the 11th week of life. Differentiation of IgG1 and IgG2 levels revealed that α-Ide_{<em>Ssuis</em>} IgG2 levels in 2-week-old suckling piglets of vaccinated sows were comparable to respective levels of prime-boost-boost vaccinated weaning piglets using a formulation with the adjuvant Emulsigen, whereas α-Ide_{<em>Ssuis</em>} IgG1 were lower in suckling piglets. Results of the intranasal challenge experiment suggested protection against morbidity in the 4th week of life against <em>S. suis cps</em>14, in agreement with results of bactericidal assays. In conclusion, this study further confirms Ide_{<em>Ssuis</em>} as a promising antigen for vaccination of sows pre-farrowing to control <em>S. suis</em> diseases.</div></div>","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100794"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “AderVax: Factors related to the acceptance or rejection of the COVID-19 vaccine in 8 cities in Colombia for the development of an intervention” [Vaccine: X 28 (2026) 100767]","authors":"Laura Juliana Valderrama-Orbegozo ,&nbsp;Laura Julieth Ramírez-Lasprilla ,&nbsp;Diana Estefanny Arce-Leonel ,&nbsp;Michell Rezene Tesfamariam-Ortega ,&nbsp;David Javier Fortich-Pérez","doi":"10.1016/j.jvacx.2026.100788","DOIUrl":"10.1016/j.jvacx.2026.100788","url":null,"abstract":"","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100788"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147420335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of psychological factors influencing attitudes and intentions toward, and uptake of, Covid-19 vaccines in adolescents","authors":"Angie Pitt ,&nbsp;Richard Amlôt ,&nbsp;Catherine Heffernan ,&nbsp;G. James Rubin ,&nbsp;Louise E. Smith","doi":"10.1016/j.jvacx.2026.100785","DOIUrl":"10.1016/j.jvacx.2026.100785","url":null,"abstract":"<div><div>Vaccination was a key measure to tackle the Covid-19 pandemic, however adolescents were less likely than adults to accept the vaccine. Low vaccine uptake reduces the effectiveness of vaccination campaigns and threatens global public health. Understanding why adolescents are hesitant to accept new vaccines is therefore crucial to support the development of novel vaccine uptake interventions. Prior reviews have included far fewer citations, excluded qualitative data orstudies after 2022 and have not mapped adolescent Covid-19 vaccine behaviour onto psychological models. This systematic review investigated psychological factors influencing attitudes and intentions toward and uptake of Covid-19 vaccines in adolescents aged 10 to 19 years globally. It mapped results onto the COM-B framework to inform future interventions. Our search identified 25,354 citations, and included 77 in this review. The quality of studies was mixed, predominantly cross-sectional in design. According to our review, key influences on adolescent Covid-19 vaccine behaviour were: i) Reflective motivation (safety concerns, perceived susceptibility to/severity of Covid-19, perceived vaccine effectiveness, ii) Social opportunity (social norms, autonomy and prosocial attitudes), iii) Psychological capability (attitude and knowledge about vaccines). Our review provides new insights into psychological factors influencing adolescent Covid-19 vaccine behaviour, and maps factors to the COM-B model of behaviour change. To improve vaccine uptake, future vaccine interventions should support adolescents to think critically about the pros and cons of vaccines and consider external influences on their decisions.</div></div>","PeriodicalId":43021,"journal":{"name":"Vaccine: X","volume":"29 ","pages":"Article 100785"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}