慢性髓性白血病累及膜迷路

IF 0.7 Q4 HEMATOLOGY Leukemia Research Reports Pub Date : 2024-01-01 DOI:10.1016/j.lrr.2024.100471
Mobachir El Kettani , Kashish Shah , Hareem Farooq , Ke Li , Talha Badar
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引用次数: 0

摘要

本病例报告解释了一名 39 岁男性慢性髓性白血病(CML)患者的特殊表现,该患者具有 T315I 突变,表现为急性双侧听力损失和失衡,继发于髓细胞暴发性危象。通过脑磁共振成像和脑脊液分析证实了神经系统受累。最初使用泊纳替尼和FLAG(氟达拉滨、阿糖胞苷、G-CSF)方案进行治疗,疗效显著,但因出现并发症而不得不停药。该患者的临床轨迹十分复杂,并发症和对酪氨酸激酶抑制剂的不耐受是其特点,这凸显了T315I突变的CML爆裂危象治疗的复杂性。识别非典型表现和早期突变分析对于定制治疗策略至关重要。
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Chronic myeloid leukemia with involvement of membranous labyrinth

This case report explains an extraordinary presentation of chronic myeloid leukemia (CML) in a 39-year-old male with a T315I mutation, presenting with acute bilateral hearing loss and imbalance secondary to myeloid blast crisis. Neurological involvement was confirmed through MRI brain and cerebrospinal fluid analysis. Initial treatment with ponatinib and FLAG (fludarabine, cytarabine, G-CSF) regimen showed promise, but complications necessitated discontinuation. The patient's complex clinical trajectory, marked by complications and intolerance to tyrosine kinase inhibitors, highlights the intricate nature of CML blast crisis with T315I mutation management. Recognizing atypical presentations and early mutation analysis are pivotal for tailored treatment strategies.

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来源期刊
Leukemia Research Reports
Leukemia Research Reports Medicine-Oncology
CiteScore
1.70
自引率
0.00%
发文量
70
审稿时长
23 weeks
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