{"title":"从Delphinium kamaonense全株中提取的四种新的莱克多宁型C19-二萜生物碱。","authors":"Xing-Yao Li, Rui-Sheng Chen, Guo-Chang Li, Kai-Cheng Du, Lan-Tao Lai, Yu-Meng Wang, Da-Li Meng","doi":"10.1080/10286020.2024.2385370","DOIUrl":null,"url":null,"abstract":"<p><p>Four new lycoctonine-type C<sub>19</sub>-diterpenoid alkaloids kamaonensines H-K (<b>1-4</b>) have been isolated from the whole plants of <i>Delphinium kamaonense</i>, together with 12 known compounds (<b>5-16</b>). Interestingly, kamaonensines <b>1-3</b> contained a rare nitrone (immine N-oxide) moiety, respectively. Their structures were established by spectroscopic analyses. The active evaluation of compounds (<b>1-16</b>) by LPS induced RAW 264.7 macrophages showed that compounds <b>4</b> and <b>8</b> displayed strong anti-inflammatory activities. While compounds <b>11</b> and <b>12</b> also showed strong cytotoxicities by the RAW 264.7 cell viability assay.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Four new lycoctonine-type C<sub>19</sub>-diterpenoid alkaloids from the whole plants of <i>Delphinium kamaonense</i>.\",\"authors\":\"Xing-Yao Li, Rui-Sheng Chen, Guo-Chang Li, Kai-Cheng Du, Lan-Tao Lai, Yu-Meng Wang, Da-Li Meng\",\"doi\":\"10.1080/10286020.2024.2385370\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Four new lycoctonine-type C<sub>19</sub>-diterpenoid alkaloids kamaonensines H-K (<b>1-4</b>) have been isolated from the whole plants of <i>Delphinium kamaonense</i>, together with 12 known compounds (<b>5-16</b>). Interestingly, kamaonensines <b>1-3</b> contained a rare nitrone (immine N-oxide) moiety, respectively. Their structures were established by spectroscopic analyses. The active evaluation of compounds (<b>1-16</b>) by LPS induced RAW 264.7 macrophages showed that compounds <b>4</b> and <b>8</b> displayed strong anti-inflammatory activities. While compounds <b>11</b> and <b>12</b> also showed strong cytotoxicities by the RAW 264.7 cell viability assay.</p>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10286020.2024.2385370\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2024.2385370","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Four new lycoctonine-type C19-diterpenoid alkaloids from the whole plants of Delphinium kamaonense.
Four new lycoctonine-type C19-diterpenoid alkaloids kamaonensines H-K (1-4) have been isolated from the whole plants of Delphinium kamaonense, together with 12 known compounds (5-16). Interestingly, kamaonensines 1-3 contained a rare nitrone (immine N-oxide) moiety, respectively. Their structures were established by spectroscopic analyses. The active evaluation of compounds (1-16) by LPS induced RAW 264.7 macrophages showed that compounds 4 and 8 displayed strong anti-inflammatory activities. While compounds 11 and 12 also showed strong cytotoxicities by the RAW 264.7 cell viability assay.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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