基线玻璃体细胞的贝赫切特综合征患者后葡萄膜炎的发展过程

IF 2.6 4区医学 Q2 OPHTHALMOLOGY Ocular Immunology and Inflammation Pub Date : 2025-02-01 Epub Date: 2024-07-30 DOI:10.1080/09273948.2024.2383315

Didar Ucar, Basak Ecem Bircan, Nigar Rustamli, Bilge Batu Oto, Vedat Hamuryudan, Gulen Hatemi, Sinem Nihal Esatoglu

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引用次数: 0

摘要

目的：贝赫切特综合征（BS）患者玻璃体细胞（VC）对预后的重要性尚不清楚。我们的目的是确定诊断时有 VC 的 BS 患者发生后葡萄膜炎（PU）的频率以及与发生 PU 相关的其他风险因素：方法：对2010年至2012年间登记的572名连续BS患者的病历进行回顾性分析。在随访时间≥2 年的患者中，我们纳入了 110 名单眼或双眼 VC 患者和 147 名双眼基线无任何眼部发现的患者，并比较了他们 PU 的发展情况：在 110 名 VC 患者中，61 人双眼均有 VC，34 人仅单眼有 VC，15 人单眼有 VC，另一眼有 PU。13名患者的基线眼除患有VC外，还患有前葡萄膜炎（AU）。这些患者中有 24 人（22%）在平均 1.9 ± 1.1 年的随访期间出现了 PU。与基线时没有任何眼部发现的 147 名患者相比，这一比例明显更高，其中只有 2 名患者出现了 PU（P 结论：PU 的发生率较低，但与基线时没有任何眼部发现的 147 名患者相比，这一比例明显更高：由于 22% 的 VC 患者在 2 年内出现了 PU，因此需要对这些患者进行仔细的随访。

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Development of Posterior Uveitis in Behçet Syndrome Patients with Vitreous Cells at Baseline.

Purpose: The prognostic importance of vitreous cells (VC) in patients with Behçet syndrome (BS) is unknown. We aimed to determine the frequency of developing posterior uveitis (PU) and any additional risk factors associated with the development of PU in BS patients with VC at diagnosis.

Methods: The charts of 572 consecutive BS patients who were registered between 2010 and 2012 were reviewed. Among the patients with a follow-up of ≥2 years, we included 110 patients with VC in one or both eyes and 147 patients without any eye findings in both eyes at baseline and compared them for the development of PU.

Results: Among the 110 included patients with VC, 61 had VC in both eyes, 34 had VC in only one eye, and 15 had VC in one eye and PU in the other eye. There was anterior uveitis (AU) in addition to VC in the same eye in 13 patients at baseline. PU developed in 24 (22%) of these patients during a mean follow-up of 1.9 ± 1.1 years. This was significantly more frequent than the 147 patients without any eye findings at baseline, among whom there were only 2 patients who developed PU (p < 0.001). Multivariate logistic regression analysis showed that having AU in addition to VC in the same eye (OR, 5.03, 95% CI; 1.37-18.47) was an independent risk factor for the development of PU in patients with VC.

Conclusion: Careful follow-up is required for patients with VC at diagnosis, since 22% developed PU within 2 years.

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.