接触六氟隆杀虫剂会诱发尼罗罗非鱼(Oreochromis niloticus)的行为改变、血液生化紊乱、抗氧化免疫功能障碍和组织病理学改变。

IF 1.8 3区 农林科学 Q2 VETERINARY SCIENCES Veterinary Research Communications Pub Date : 2024-10-01 Epub Date: 2024-07-31 DOI:10.1007/s11259-024-10467-0
Rowida E Ibrahim, Moustafa M S Fouda, Abdelwahab A Abdelwarith, Elsayed M Younis, Eman Wagih, Basma A Elshafey, Simon J Davies, Afaf N Abdel Rahman
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引用次数: 0

摘要

六氟磺隆(HEX)杀虫剂被广泛应用于农业生产中防治农作物害虫。本研究调查了六氟磺隆对尼罗罗非鱼(Oreochromis niloticus)的毒理学影响。将 240 尾鱼(35.50 ± 1.45 克)分成 6 组,每组 40 尾,每组 10 尾,共 4 个重复,暴露于 6 种不同浓度的六六六(0、2、4、6、8 和 10 毫克/升-1)中 96 小时。经计算,96 小时的 HEX 致死浓度 50(96-h LC50)为 7.19 mg L-1。暴露于 HEX 后,鱼类的表层和中层游动、攻击性和展尾行为减少,底层游动和静止行为增加。暴露于 HEX 会导致鱼体出血和鳍腐烂。接触六六六后,红细胞图(红细胞计数、血红蛋白和充盈细胞体积百分比)显著减少,平均血球容积增加。接触六六六会降低白细胞(WBCs)和白细胞差值计数。急性接触六六六会提高 8-羟基-2-脱氧鸟苷水平,同时降低脑乙酰胆碱酯酶活性。暴露于六羟环己烷会导致肝肾功能障碍,并增加应激相关参数(葡萄糖和皮质醇)。暴露于 HEX 会降低免疫反应(溶菌酶、一氧化氮、免疫球蛋白 M 和补体 3)。暴露于 HEX 后,抗氧化变量(还原型谷胱甘肽含量和过氧化氢酶)大幅减少,丙二醛含量增加。此外,接触过氧化氢还导致鱼鳃、肝脏、肾脏和脾脏发生组织病理学变化。这些结果表明,接触六六六会诱发行为变化、肝肾功能障碍和免疫抗氧化紊乱,表明尼罗河鱼可能存在生理紊乱。
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Hexaflumuron insecticide exposure induces behavior alterations, hemato-biochemical disorders, antioxidant-immune dysfunction, and histopathological alterations in Nile tilapia (Oreochromis niloticus).

Hexaflumuron (HEX) insecticide is widely used in agriculture practices to fight crop insects. The toxicological effect of HEX on Nile tilapia (Oreochromis niloticus) was investigated in this study. Two hundred and forty fish (35.50 ± 1.45 g) were divided into six groups in four replicates (40 fish/group; 10 fish/replicate) and were exposed to six distinct HEX concentrations (0, 2, 4, 6, 8, and 10 mg L-1) for 96-h. The 96-h lethal concentration 50 (96-h LC50) of HEX was calculated to be 7.19 mg L-1. The fish exhibited reduced surface and middle swimming, aggressiveness, and tail-spreading behaviors with increasing bottom swimming and resting patterns after HEX exposure. HEX exposure resulted in body bleeding and fin rot. The erythrogram (red blood cell count, hemoglobin, and packed cell volume %) was significantly reduced with increased mean corpuscular volume by HEX exposure. HEX exposure decreased the white blood cells (WBCs) and differential WBC counts. Acute HEX exposure raised 8-hydroxy-2-deoxyguanosine level while lowering brain acetylcholine esterase activity. HEX exposure caused hepato-renal dysfunction and increased stress-related parameters (glucose and cortisol). Exposure to HEX reduced the immune responses (lysozyme, nitric oxide, immunoglobulin M, and complement 3). A substantial decrease in the antioxidant variables (reduced glutathione content and catalase) with increasing the malondialdehyde was noted by HEX exposure. Moreover, histopathological changes resulted from HEX exposure in the gills, liver, kidney, and spleen. These results indicate that HEX exposure induced behavioral changes, hepato-renal dysfunction, and immune-antioxidant disruption, indicating a possible physiological disruption in O. niloticus.

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来源期刊
Veterinary Research Communications
Veterinary Research Communications 农林科学-兽医学
CiteScore
2.50
自引率
0.00%
发文量
173
审稿时长
3 months
期刊介绍: Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial. The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.
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