利用希腊拜占庭早期(公元 500-700 年)奥林匹亚新发现的 Legg-Calvé-Perthes 病例测试古代罕见疾病数字图谱 (DAARD)。

IF 1.3 3区 地球科学 Q3 PALEONTOLOGY International Journal of Paleopathology Pub Date : 2024-07-29 DOI:10.1016/j.ijpp.2024.07.002
Yannick Ahlbrecht , Oliver Pilz , Julia Gresky
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引用次数: 0

摘要

目的:介绍希腊首例莱格-卡尔维-珀特氏病(LCPD)病例。我们利用古代罕见疾病数字图谱(DAARD)对 LCPD 这种罕见疾病进行了讨论,并通过 DAARD 中记录的 42 例 LCPD 考古病例,检验了该数据库在诊断新病例和确定病例背景方面的优势:材料:在希腊奥林匹亚考古遗址中发现了一个 30-40 岁的疑似男性个体,年代为公元 500-700 年:方法:采用宏观和骨计量学方法对生物性别、死亡年龄和病理变化进行了研究。DAARD 提供了 LCPD 的典型特征:结果:两个髋关节的病理变化与 LCPD 的骨骼特征相符,但骨骼中没有任何其他相关变化。DAARD产生了42例LCPD病例,其中大部分来自欧洲,男性居多,单侧髋关节受累:结论:DAARD 有助于诊断罕见疾病,并在已知研究的背景下解释新病例:本研究表明,DAARD 有可能帮助研究人员超越单个病例研究的水平,为罕见病的历史绘制更广阔的图景:局限性:本文重点介绍了 DAARD 在 LCPD 方面的优势,但并非所有罕见疾病都已纳入数据库:进一步研究的建议:应将更多考古学背景下的罕见疾病添加到 DAARD 中,为解释这些疾病的历史奠定基础,并扩大我们对过去罕见疾病的了解。
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Testing the Digital Atlas of Ancient Rare Diseases (DAARD) using a new case of Legg-Calvé-Perthes disease from Early Byzantine (500–700 CE) Olympia, Greece

Objective

The first case of Legg-Calvé-Perthes disease (LCPD) in Greece is presented. LCPD, a rare disease, is discussed using the Digital Atlas of Ancient Rare Diseases (DAARD), which tests the benefits of the database for diagnosing and contextualizing the new case with 42 archaeological cases of LCPD recorded in the DAARD.

Materials

A 30–40-year-old, probable male individual was found at the archaeological site of Olympia, Greece, dating to 500–700 CE.

Methods

Biological sex, age-at-death and pathological changes were investigated using macroscopic and osteometric methods. The DAARD provided the typical characteristics of LCPD.

Results

Pathological changes in both hip joints without any other related changes in the skeleton corresponded to the skeletal features of LCPD. The DAARD produced 42 cases of LCPD, most of which from Europe, with a preference for male sex and unilateral involvement of the hip joint.

Conclusions

The DAARD aids in diagnosing rare diseases and interpreting new cases in the context of already known studies.

Significance

This study shows that the DAARD has the potential to help researchers move beyond the level of single case studies and create a broader picture of the history of rare diseases.

Limitations

This paper focuses on the benefits of the DAARD in relation to LCPD but not all rare diseases have been included in the database.

Suggestions for further research

More rare diseases from archaeological contexts should be added to the DAARD to create a base for the interpretation of their history and expand our understanding of rare diseases in the past.

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来源期刊
CiteScore
2.90
自引率
25.00%
发文量
43
期刊介绍: Paleopathology is the study and application of methods and techniques for investigating diseases and related conditions from skeletal and soft tissue remains. The International Journal of Paleopathology (IJPP) will publish original and significant articles on human and animal (including hominids) disease, based upon the study of physical remains, including osseous, dental, and preserved soft tissues at a range of methodological levels, from direct observation to molecular, chemical, histological and radiographic analysis. Discussion of ways in which these methods can be applied to the reconstruction of health, disease and life histories in the past is central to the discipline, so the journal would also encourage papers covering interpretive and theoretical issues, and those that place the study of disease at the centre of a bioarchaeological or biocultural approach. Papers dealing with historical evidence relating to disease in the past (rather than history of medicine) will also be published. The journal will also accept significant studies that applied previously developed techniques to new materials, setting the research in the context of current debates on past human and animal health.
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