评估邻苯二甲酸二(2-乙基己酯)(DEHP)对秀丽隐杆线虫存活率和繁殖力的影响。

IF 3.1 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Applied Biochemistry and Biotechnology Pub Date : 2024-08-01 DOI:10.1007/s12010-024-05032-z
Alper Zöngür
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引用次数: 0

摘要

二-2-乙基己基(DEHP)广泛用于工业产品,全球年产量超过 200 万吨。DEHP 是一种内分泌干扰物,也是自然界中主要的环境污染化学品(EDCs)之一。有一些信息表明,这些在各方面都具有巨大优势的产品会对人类健康和环境产生影响。本研究利用秀丽隐杆线虫来评估 DEHP 的健康和环境风险。研究人员检测了 DEHP 对 elegans 的生存和生育影响,并对结果进行了评估。研究结果表明,DEHP 不仅会缩短 elegans 的存活时间,还会降低其生育能力。DEHP(0.625 mM 和 10 mM)会导致生育能力下降 23.2-30.6% 。此外,还发现 DEHP 的 LC50(50%致死浓度)值为 321 µg/mL。
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Evaluation of the Effects of Di-(2-ethylhexyl) phthalate (DEHP) on Caenorhabditis elegans Survival and Fertility.

Di-2-ethylhexyl (DEHP), which is widely used in industrial products, is produced annually in excess of 2 million tons worldwide. DEHP is an endocrine disruptor and one of the major environmental pollutant chemicals (EDCs) in nature. There is some information about the effects of these products, which provide great advantages in every respect, on human health and the environment. In this study, C. elegans organism was used to evaluate the health and environmental risks of DEHP. The survival and fertility effects of DEHP on the C. elegans organism were examined and the results were evaluated. In the study, it was determined that DEHP not only shortened the survival time of C. elegans but also caused a decrease in fertility. DEHP (0.625 mM and 10 mM) caused a 23.2-30.6% decrease in fertility. Additionally, the LC50 (50% lethal concentration) value of DEHP was found to be 321 µg/mL.

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来源期刊
Applied Biochemistry and Biotechnology
Applied Biochemistry and Biotechnology 工程技术-生化与分子生物学
CiteScore
5.70
自引率
6.70%
发文量
460
审稿时长
5.3 months
期刊介绍: This journal is devoted to publishing the highest quality innovative papers in the fields of biochemistry and biotechnology. The typical focus of the journal is to report applications of novel scientific and technological breakthroughs, as well as technological subjects that are still in the proof-of-concept stage. Applied Biochemistry and Biotechnology provides a forum for case studies and practical concepts of biotechnology, utilization, including controls, statistical data analysis, problem descriptions unique to a particular application, and bioprocess economic analyses. The journal publishes reviews deemed of interest to readers, as well as book reviews, meeting and symposia notices, and news items relating to biotechnology in both the industrial and academic communities. In addition, Applied Biochemistry and Biotechnology often publishes lists of patents and publications of special interest to readers.
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